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*平成23年度国立情報学研究所最先端学術情報基盤(CSI)構築推進委託事業です。

kuir is 6477
total is 7043
High-pressure carbon monoxide and oxygen mixture is effective for lung preservation 藤原 敦史 Fujiwara Atsushi
Abstract (1) Background: Heme oxygenase-1 (HO-1) degrades heme and generates carbon monoxide (CO), producing various anti-inflammatory, anti-oxidative, and anti-apoptotic effects. This study aimed to confirm the effects of CO on the ischemia-reperfusion injury (IRI) of donor lungs using a high-pressure gas (HPG) preservation method. (2) Methods: Donor rat and canine lungs were preserved in a chamber filled with CO (1.5 atm) and oxygen (O2; 2 atm) and were ventilated with either CO and O2 mixture (CO/O2 group) or air (air group) immediately before storage. Rat lungs were subjected to heterotopic cervical transplantation and evaluated after reperfusion, whereas canine lungs were subjected to allogeneic transplantation and evaluated. (3) Results: Alveolar hemorrhage in the CO/O2 group was significantly milder than that in the air group. mRNA expression levels of HO-1 remained unchanged in both the groups; however, inflammatory mediator levels were significantly lower in the CO/O2 group than in the air group. The oxygenation of graft lungs was comparable between the two groups, but lactic acid level tended to be higher in the air group. (4) Conclusions: The HO-1/CO system in the HPG preservation method is effective in suppressing IRI and preserving donor lungs. KEYWORDS: carbon monoxide; high-pressure gas; ischemia–reperfusion injury; lung preservation (医博甲728)

Relationships between Physical Activity, Sleeping Time, and Psychological Distress in Community-Dwelling Elderly Japanese 山本 幸男 Yamamoto Yukio
Abstract Background and objectives: It is well-known that lifestyle is closely associated with psychological distress in many elderly subjects. However, the effect of intervention with physical activity and/or sleeping on psychological distress has not been fully discussed. The purpose of this cross-sectional study was to investigate the relationships between physical activity, sleeping time, and psychological distress in community-dwelling elderly Japanese subjects. Materials and Methods: A total of 108 elderly Japanese (31 men and 77 women) subjects were enrolled in this cross-sectional study. Psychological distress was evaluated using the K6 questionnaire. Physical activity, including sedentary behavior, was measured using a tri-accelerometer. Sleeping time was evaluated using a self-reported questionnaire. Results: The median of the K6 scores was 1.0 (0-18), and the sedentary behavior (%) and walking time (minutes/day) were 57.2 ± 10.7 and 80.7 (17.9-222.4), respectively. Sleeping time was negatively correlated with psychological distress. In addition, multiple linear regression showed that walking time and sleeping time were important factors for psychological distress, even after adjusting for confounding factors. Conclusions: These results suggest that increased walking time and sleeping time may be beneficial for reducing psychological distress in community-dwelling elderly Japanese subjects. Keywords: physical activity; psychological distress; sedentary behavior; sleeping; walking. (医博甲727)

Change in fetal behavior in response to vibroacoustic stimulation 小河 佳織 Ogo Kaoru
Abstract Objective To assess fetal behavioral changes in response to vibroacoustic stimulation (VAS) in normal singleton pregnancies using four-dimensional (4D) ultrasound. Methods Ten types of fetal movements and facial expressions in 68 healthy pregnant women between 24 and 40 weeks were studied using 4D ultrasound for 3 min before and after 3-s VAS. The frequencies of mouthing, yawning, tongue expulsion, back arch, jerky arm movement, startle movement, smiling, scowling, hand-to-face movement, and blinking were evaluated. The fetuses were subdivided into four gestational age groups (24-27, 28-31, 32-35, and ≥36 weeks). Comparison of the frequencies of the fetal behaviors before and after the stimulation in each gestational age group was conducted to detect the response to stimulation with advancing gestation. Results There were no significant differences in the frequency of each fetal behavior before and after VAS at 24-27, 28-31, and 32-35 weeks of gestation. However, the frequencies of blinking and startle movements were significantly higher after VAS in the 36-40 gestational age group (P < 0.05). Conclusion The age of 36 weeks of gestation might represent an advanced stage of brain and central nervous system development and maturation as the response to stimuli is prominent at this age compared with earlier gestation. Keywords: 4D ultrasound; fetal CNS development; fetal CNS maturation; fetal behavior; fetal stress; vibroacoustic stimulation. (医博甲726)

裏表紙・英文目次


大賀睦夫教授年譜・著作目録


斉藤和也教授年譜・著作目録


閑暇における共歓 斉藤 和也 Kazunari Saito


ソシュールの伝説・神話研究における歴史の概念 金澤 忠信 Tadanobu Kanazawa


斉藤和也先生・大賀睦夫先生を送る 佐藤 忍 Shinobu Sato


表紙・目次


保育所や幼稚園等と小学校との連携・接続について-理解を深めていく授業展開についての考察- 佐々木 利子


プロスポーツチーム組織におけるフロントスタッフの役割と仕事:「ホームゲーム」の産出に着目して 宇野 博武


研究授業「教育学原論」の報告 相馬 宗胤


研究授業「文書実務」の実施報告 佐藤 麻衣


研究授業「医療秘書概論」の実施報告 秋鹿 悦子


小学校外国語指導法について~「気付き」を促す指導~ 竹田 忠弘


生産性向上についての一考察―日本企業を対象として― 岡本 丈彦


研究授業「コミュニケーション演習Ⅱ」の実施報告 森 享子 蓮井 孝夫


Google Classroomを用いた授業管理の利点と問題点 山口 直木


プロスポーツ経営研究の動向と課題 宇野 博武