D-psicose inhibits intestinal α-glucosidase and suppresses glycemic response after carbohydrate ingestion in rats

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/1281
Title
D-psicose inhibits intestinal α-glucosidase and suppresses glycemic response after carbohydrate ingestion in rats
Title Alternative
D-プシコースは小腸α-グリコシダーゼを阻害し,ラットにおける炭水化物摂取後の血糖値上昇反応を抑制する
File
Description

D-Psicose in one of rare sugars present in small quantities in commercial carbohydrates and agricultural products. In this study, we investigate the effects of D-psicose on the activities of α-amylases and α-glucosidases in vitro, and evaluate the effects of D-psicose on postprandial glycemic response using rats in vivo. In vitro study, D-psicose potently inhibited intestinal sucrase and maltase. however, slightly inhibited intestinal and salivary α-amylase activities. Male Wistar rats (6 months old) were administrated 2 g/kg of sucrose, maltose or soluble starch together with 0.2 g/kg of D-psicose or D-fructose. D-Psicose significantly inhibited the increment of plasma glucose concentration induced by sucrose or maltose. Starch-induced glycemic response tended to be suppressed by D-psicose, however the suppression was not significant. These results suggest that D-psicose inhibits intestinal sucrase and maltase activities in an uncompetitive manner and suppresses the plasma glucose increase after sucrose and maltose ingestion. Thus, D-psicose may be useful in proventing postprandial hyperglycemia in diabetic patients when foods containing sucrose and maltose are ingested.

Author
著者 Matsuo Tatsuhiro
著者(ヨミ) マツオ タツヒロ
著者(別表記) 松尾 達博
著者 Izumori Ken
著者(ヨミ) イズモリ ケン
著者(別表記) 何森 健
Publication Title
香川大学農学部学術報告
Volume
58
Start Page
27
End Page
32
Publisher
香川大学農学部
Published Date
20060215
ISSN
0368-5128
NCID
AN00038339
Resource Type
Departmental Bulletin Paper
Language
eng
Text Version
publisher
Set
香川大学
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