Assessment of sensory perception and processing using current perception threshold in Parkinson's disease

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27462
タイトル
Assessment of sensory perception and processing using current perception threshold in Parkinson's disease
ファイル
内容記述

Abstract
Aim

Although peripheral deafferentation is one of the causes of abnormal sensory processing in Parkinson's disease (PD), functional assessment of different‐size sensory nerve populations remains insufficient.

We assessed the characteristics of sensory perception and processing in PD patients using current perception threshold (CPT).
Methods

A total of 28 patients with PD, 20 with multiple system atrophy (MSA) and 28 healthy controls underwent CPT examination using a Neurometer device, which can selectively stimulate A‐β fibers at 2000 Hz, A‐δ fibers at 250 Hz and C fibers at 5 Hz.
Results

Significant differences in CPT for all stimulus frequencies were observed among the three groups. PD patients had significantly higher CPT for all stimulus frequencies than control individuals (P < 0.05). Also, PD patients had significantly higher CPT for 250 and 5 Hz than MSA patients (P < 0.05). At the optimum cut‐off level, the CPT distinguished PD patients from MSA patients with a high sensitivity (82% at 250 Hz, 86% at 5 Hz) and specificity (75% at 250 Hz, 80% at 5 Hz). The CPT were not affected by clinical profile, cardiac sympathetic denervation or cardiovascular autonomic dysfunction.
Conclusion

Significantly increased CPT in PD indicate altered processing of sensory information involving A‐β, A‐δ and C fibers. The clear distinction of CPT between PD and MSA might reflect the involvement in small fiber dysfunction in PD, but not in MSA. These findings suggest that CPT testing might contribute to diagnosis of PD, as well as the understanding of sensory processing involving peripheral deafferentation.

(医博甲579)

著者
著者 池田 和代
著者(ヨミ) イケダ カズヨ
著者(別表記) Ikeda Kazuyo
掲載誌
Neurology and Clinical Neuroscience
1
6
出版者
Wiley
出版年月日
2013-09-30
ISSN
2049-4173
DOI
10.1111/ncn3.55
資料タイプ
学位論文
言語
英語
関連情報URL
https://doi.org/10.1111/ncn3.55
該当なし
学位授与番号
博甲第579号
学位授与年月日
2013-12-26
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
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