Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27467
Title
Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice
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Description

Abstract

The present study was conducted to investigate the effects of gonadectomy on lung carcinogenesis in female and male mice, and to determine an association between sex hormone and lung carcinogenesis. Female and male A/J mice were divided into gonadectomized and unoperated control groups and all animals were treated intraperitoneally with 1 or 2 injections of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at the dose of 2 mg/mouse. The mice were sacrificed 18 or 56 weeks after surgery. Serum levels of estradiol in females and testosterone in males were confirmed to be decreased by gonadectomy. Lung white nodules were detected in all mice of all groups. In the control groups of 18- and 56-week studies, the multiplicities of lung nodules in females were significantly greater than in males. In males in the 56-week study, the multiplicity of macroscopical lung nodules, bronchiolo-alveolar hyperplasias, adenomas and tumors (adenomas and adenocarcinomas) showed significant increase with castration. In females in the 18-week study, the multiplicity of adenomas decreased significantly by ovariectomy. Based on the results of the present study, female A/J mice were confirmed to be more susceptible to NNK-induced lung carcinogenesis than males. Furthermore, it was suggested that the process is inhibited by testosterone and accelerated by estradiol. These findings indicate the possibility that sex hormones play important roles in determining sex differences in lung carcinogenesis in the A/J mice initiated by NNK.

Keywords: lung tumorigenesis, gonadectomy, sex hormone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, A/J mouse

(医博甲584)

Author
著者 二宮 芙美子
著者(ヨミ) ニノミヤ フミコ
著者(別表記) Ninomiya Fumiko
Publication Title
Oncology Reports
Publication Title Alternative
Oncol Rep.
Volume
30
Issue
6
Start Page
2632
End Page
2638
Publisher
Spandidos Publications
Published Date
2013-10-01
ISSN
1021-335X
NCID
AA11016405
PMID
24085151
DOI
10.3892/or.2013.2759
Resource Type
Thesis or Dissertation
Language
eng
Relation
PMCID: PMC3839949
Resource URL
https://doi.org/10.3892/or.2013.2759
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839949/
Rights
Copyright © Spandidos Publications 2013.
"This is the Publisher's Version of the following article: Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice; Oncology Reports; Volume 30 Issue 6 (2013) Pages: 2632-2638; doi: 10.3892/or.2013.2759, which has been published in final form at https://doi.org/10.3892/or.2013.2759 . "
Text Version
ETD
Grant ID
博甲第584号
Grant Date
2014-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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