Correlation of 18F-fluoromisonidazole PET findings with HIF-1α and p53 expressions in head and neck cancer: comparison with 18F-FDG PET

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27469
Title
Correlation of 18F-fluoromisonidazole PET findings with HIF-1α and p53 expressions in head and neck cancer: comparison with 18F-FDG PET
File
Description

Abstract
OBJECTIVE:

We evaluated tumor hypoxia using F-fluoromisonidazole (F-FMISO) PET in relation to the expression of hypoxia-inducible factor-1α (HIF-1α) and p53 in patients with head and neck cancer and compared the results with those obtained using 2-deoxy-2-F-fluoro-D-glucose (F-FDG) PET.
MATERIALS AND METHODS:

A total of 28 tumors (23 primary tumors and five metastatic lymph nodes) from 24 patients with newly diagnosed head and neck cancer were examined with F-FMISO PET and F-FDG PET. The F-FMISO PET images were scaled to the venous blood concentration of F-FMISO activity to produce tumor-to-blood (T/B) values. Hypoxia was defined as a region with a T/B ratio greater than or equal to 1.2. The maximum T/B (T/Bmax) and hypoxic volumes were calculated by region-of-interest analysis. For F-FDG PET, the maximum standardized uptake value (SUVmax) and hypermetabolic volume were calculated by region-of-interest analysis. The expressions of HIF-1α and p53 using immunohistochemistry were estimated in tumor tissue samples.
RESULTS:

A weak correlation was observed between hypoxic volume and T/Bmax (r=0.53, P=0.003) on using F-FMISO PET and between hypermetabolic volume and SUVmax (r=0.38, P=0.046) on using F-FDG PET. The hypoxic volume using F-FMISO PET and hypermetabolic volume using F-FDG PET also showed a weak correlation (r=0.44, P=0.020). The values of F-FMISO hypoxic volume showed a weak correlation with HIF-1α (r=0.40, P=0.037) and p53 (r=0.47, P=0.012) obtained on immunohistochemical examination.
CONCLUSION:

This study demonstrates a weak correlation between hypoxic volume measured by F-FMISO PET and expressions of HIF-1α and p53 in head and neck cancer.

(医博甲586)

Author
著者 則兼 敬志
著者(ヨミ) ノリカネ タカシ
著者(別表記) Norikane Takashi
Publication Title
Nuclear Medicine Communications
Publication Title Alternative
Nucl Med Commun.
Volume
35
Issue
1
Start Page
30
End Page
35
Publisher
British Nuclear Medicine Society
Lippincott, Williams & Wilkins
Published Date
2014-01
ISSN
0143-3636
NCID
AA10624879
PMID
24121312
DOI
10.1097/MNM.0000000000000010
Resource Type
Thesis or Dissertation
Language
eng
Relation URL(Replaces)
https://doi.org/10.1097/MNM.0000000000000010
Text Version
none
Grant ID
博甲第586号
Grant Date
2014-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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