The impact of baseline [-2]proPSA-related indices on the prediction of pathological reclassification at 1 year during active surveillance for low-risk prostate cancer: the Japanese multicenter study cohort

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27473
Title
The impact of baseline [-2]proPSA-related indices on the prediction of pathological reclassification at 1 year during active surveillance for low-risk prostate cancer: the Japanese multicenter study cohort
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Description

Abstract
PURPOSE:

Active surveillance (AS) is one potential solution to avoiding the overtreatment of favorable prostate cancer. By handling the AS strategy more safely, tumor aggressiveness may be evaluated more accurately. The aim of the present study was to evaluate the predictive impact of baseline prostate-specific antigen (PSA) isoform [-2]proPSA (p2PSA)-related indices on the pathological reclassification at 1 year during an AS program.
METHODS:

Between 2002 and 2003, 134 males diagnosed with low-risk prostate cancer were registered in the Japanese multicenter study cohort as candidates for AS, and 118 (88 %) males actually proceeded to AS. Of the 118 patients, the 67 that underwent protocol biopsy at 1 year after beginning AS were enrolled in the present study. The predictive significance of various baseline clinicopathological features and p2PSA-related indices on pathological reclassification at 1 year after beginning AS were investigated.
RESULTS:

The pathological reclassification rate was 37.3 %. According to the univariate analysis, prostate volume (p = 0.049), number of biopsy cores (p = 0.047), percentage of positive biopsy cores (p = 0.023), p2PSA to free PSA ratio (%p2PSA) (p = 0.003) and prostate health index (phi) (p = 0.010) at baseline were significantly different between the reclassification and non-reclassification groups. By multivariate logistic regression analysis, baseline %p2PSA (p = 0.008) and phi (p = 0.008) were the only independent predictive factors for pathological upgrade at 1 year after AS commencement.
CONCLUSIONS:

Baseline %p2PSA and phi may predict the pathological reclassification at 1 year after starting AS, which could be due to the under detection of clinically significant prostate cancer at AS enrollment.

(医博甲590)

Author
著者 平間 裕美
著者(ヨミ) ヒラマ ヒロミ
著者(別表記) Hirama Hiromi
Publication Title
Journal of Cancer Research and Clinical Oncology
Publication Title Alternative
J Cancer Res Clin Oncol.
Volume
140
Issue
2
Start Page
257
End Page
263
Publisher
Deutsche Krebsgesellschaft
Springer (part of Springer Nature)
Published Date
2013-12-19
ISSN
0171-5216
NCID
AA0025708X
PMID
24352745
DOI
10.1007/s00432-013-1566-2
Resource Type
Thesis or Dissertation
Language
eng
Relation
PMCID: PMC3895184
Resource URL
https://doi.org/10.1007/s00432-013-1566-2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895184/
Text Version
none
Grant ID
博甲第590号
Grant Date
2014-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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