Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27476
Title
Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3
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Description

Abstract

Galectin-9 ameliorates various murine autoimmune disease models by regulating T cells and macrophages, although it is not known what role it may have in B cells. The present experiment shows that galectin-9 ameliorates a variety of clinical symptoms, such as proteinuria, arthritis, and hematocrit in MRL/lpr lupus-prone mice. As previously reported, galectin-9 reduces the frequency of Th1, Th17, and activated CD8(+) T cells. Although anti-dsDNA antibody was increased in MRL/lpr lupus-prone mice, galectin-9 suppressed anti-dsDNA antibody production, at least partly, by decreasing the number of plasma cells. Galectin-9 seemed to decrease the number of plasma cells by inducing plasma cell apoptosis, and not by suppressing BAFF production. Although about 20% of CD19(-/low) CD138(+) plasma cells expressed Tim-3 in MRL/lpr lupus-prone mice, Tim-3 may not be directly involved in the galectin-9-induced apoptosis, because anti-Tim-3 blocking antibody did not block galectin-9-induced apoptosis. This is the first report of plasma cell apoptosis being induced by galectin-9. Collectively, it is likely that galectin-9 attenuates the clinical severity of MRL lupus-prone mice by regulating T cell function and inducing plasma cell apoptosis.

(医博甲571)

Author
著者 守時 政宏
著者(ヨミ) モリトキ マサヒロ
著者(別表記) Moritoki Masahiro
Publication Title
PLoS ONE
Publication Title Alternative
PLoS One.
Volume
8
Issue
4
Start Page
e60807
End Page
e60807
Publisher
Public Library of Science
Published Date
2013-04-09
ISSN
1932-6203
PMID
23585851
DOI
10.1371/journal.pone.0060807
Resource Type
Thesis or Dissertation
Language
eng
Relation
PMCID: PMC3621869
Resource URL
https://doi.org/10.1371/journal.pone.0060807
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621869/
Rights
Copyright © 2013 Moritoki et al
This is an open-access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
DOI: https://doi.org/10.1371/journal.pone.0060807
Text Version
ETD
Grant ID
博甲第571号
Grant Date
2013-06-25
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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