Higher methotrexate dose is associated with lymphoproliferative disorders onset in rheumatoid arthritis patients

( Max 2000 Items )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27629
Title
Higher methotrexate dose is associated with lymphoproliferative disorders onset in rheumatoid arthritis patients
File
Description

Abstract
OBJECTIVE:

Methotrexate (MTX) is used as an anchor drug for rheumatoid arthritis (RA). Lymphoproliferative disease (LPD) occasionally develops in patients treated with MTX, and is known as MTX-associated LPD (MTX-LPD). Although MTX-LPD occurs mainly in RA patients, it has not been established if MTX administration is an independent risk factor for LPD in RA patients. We examined the clinical characteristics of MTX-LPD in Japanese RA patients and attempted to determine the risk factors for MTX-LPD development.
METHODS:

We performed a nested case-control study on RA patients. We enrolled 5,753 RA patients from Kagawa, Japan. In age- and sex-matched patients, we separated patients who did not develop LPD under MTX treatment (MTX non-LPD group) from those that did (MTX-LPD group) and conducted a comparative examination. We used multivariate analysis to determine the independent risk factors for MTX-LPD onset.
RESULTS:

There were 28 patients in the MTX-LPD group and 125 patients in the MTX non-LPD group. Multivariate analysis of the parameters extracted by univariate analysis revealed that the mean MTX dose was a risk factor for MTX-LPD after adjusting for age; therefore, higher MTX dose is associated with LPD onset in RA patients.
CONCLUSION:

MTX is an independent risk factor for LPD onset in Japanese RA patients.

(医博乙269)

Author
著者 亀田 智広
著者(ヨミ) カメダ トモヒロ
著者(別表記) Kameda Tomohiro
Publication Title
Arthritis Care and Research
Publication Title Alternative
Arthritis Care Res (Hoboken).
Volume
66
Issue
9
Start Page
1302
End Page
1309
Publisher
American College of Rheumatology
Wiley
Published Date
2014-09
ISSN
2151-464X
NCID
AA10706168
PMID
24515570
DOI
10.1002/acr.22306
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1002/acr.22306
Text Version
none
Grant ID
博乙第269号
Grant Date
2014-09-17
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.