The combination of OLmesartan and a CAlcium channel blocker (azelnidipine) or candesartan and a calcium channel blocker (amlodipine) in type 2 diabetic hypertensive patients: The OLCA study

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27631
Title
The combination of OLmesartan and a CAlcium channel blocker (azelnidipine) or candesartan and a calcium channel blocker (amlodipine) in type 2 diabetic hypertensive patients: The OLCA study
File
Description

Abstract

Angiotensin II receptor blockers (ARB) are often co-administered with a calcium channel blocker (CCB) for treating hypertension. In this open-label randomised study, untreated diabetic hypertensive patients were randomised to receive either olmesartan 20 mg/day or candesartan 8 mg/day for 12 weeks. Patients with blood pressure exceeding 130/80 mm Hg received add-on 16 mg/day azelnidipine to ongoing olmesartan (OL group) or 5 mg/day amlodipine to ongoing candesartan (CA group) for 24 weeks. Home-measured and clinic-measured blood pressure decreased in both groups. Fasting blood glucose, haemoglobin A1c (HbA1c) and urinary albumin levels decreased significantly in the OL group but not in the CA group. In conclusion, this study revealed clinically relevant differences between two combinations of an ARB+CCB in diabetic hypertensive patients. Olmesartan and azelnidipine had a more persistent early morning antihypertensive effect and produced greater decreases in heart rate, fasting blood glucose and HbA1c (National Glycohemoglobin Standardization Program values) levels, and microalbuminuria than did candesartan and amlodipine.

(医博乙271)

Author
著者 大工原 裕之
著者(ヨミ) ダイクハラ ヒロユキ
著者(別表記) Daikuhara Hiroyuki
Publication Title
Diabetes and Vascular Disease Research
Publication Title Alternative
Diab Vasc Dis Res.
Volume
9
Issue
4
Start Page
280
End Page
286
Publisher
SAGE Publications
International Society of Diabetes and Vascular Disease
Published Date
2012-06-20
ISSN
1479-1641
NCID
AA11969592
PMID
22718810
DOI
10.1177/1479164112447310
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1177/1479164112447310
Text Version
none
Grant ID
博乙第271号
Grant Date
2015-02-18
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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