The phytotherapeutic agent, eviprostat, suppresses stromal proliferation and inflammation even after establishment of nonbacterial prostatitis in the rat prostate

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27633
Title
The phytotherapeutic agent, eviprostat, suppresses stromal proliferation and inflammation even after establishment of nonbacterial prostatitis in the rat prostate
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Description

Abstract
OBJECTIVE:

To evaluate the effect of phytotherapeutic agent, Eviprostat, administered after the establishment of nonbacterial prostatitis (NBP) on the stroma-to-epithelium ratio (S/E ratio), inflammatory scores, tissue macrophage infiltration, and cytokines and chemokines levels in prostate tissue and urine.
MATERIALS AND METHODS:

Ten-month-old male Wistar rats were castrated and exposed to 17-beta-isomer of estradiol for 30 days to induce NBP. Twenty-five NBP rats were divided into 5 groups: (1) NBP (0) rats sacrificed immediately after the establishment of NBP; (2,3) NBP (30)/control (CTL) and NBP (30)/Eviprostat (EVI) rats fed without or with 0.1% Eviprostat under estradiol-free for 30 days, respectively; and (4,5) NBP (60)/CTL and NBP (60)/EVI rats fed without or with 0.1% Eviprostat under estradiol-free for 60 days, respectively. The S/E ratio, inflammatory scores, and the number of macrophage infiltration in the prostate were assessed. Concentrations of cytokines and chemokines in prostatic tissue and urine were measured by enzyme-linked immunosorbent assay.
RESULTS:

The S/E ratio was significantly increased with time until 60 days under estradiol-free condition (P <.001). The S/E ratio and the inflammatory scores in NBP (60)/EVI was significantly lower than that of NBP (60)/CTL (P <.001, and P = .022, respectively). The mean tissue concentration of chemokine ligand 2 (CCL2)/monocyte chemoattractant protein-1 (MCP-1) in NBP (60)/CTL was significantly higher than that in NBP (0) (P = .016), whereas, there was no difference between NBP (60)/EVI and NBP (0). Furthermore, urinary CCL2/MCP-1 was significantly decreased in NBP (60)/EVI as compared with NBP (0) (P = .028).
CONCLUSION:

Eviprostat suppresses the stromal proliferation and inflammation in the rat prostate after the establishment of NBP at least partly owing to inhibitory effect on CCL2/MCP-1 production in the prostate.

(医博甲594)

Author
著者 渋谷 信介
著者(ヨミ) シブヤ シンスケ
著者(別表記) Shibuya Shinsuke
Publication Title
Urology
Publication Title Alternative
Urology.
Volume
83
Issue
3
Start Page
528
End Page
534
Publisher
Societe Internationale d' Urologie
Elsevier
Published Date
2013-11
ISSN
0090-4295
NCID
AA0087924X
PMID
24581515
DOI
10.1016/j.urology.2013.11.033
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1016/j.urology.2013.11.033
Rights
Copyright © 2014 Elsevier Inc.
この博士論文の本文については、次のエルゼビアの著作権ポリシーの規定により公開しています。「博士論文の場合は、エンバーゴ期間に関係なく機関リポジトリに出版社版を公開することができます。」 The text of this doctoral dissertation is published according to the following Elsevier copyright policy. "In the case of doctoral dissertations, publishers can be published in institutional repositories regardless of the Embargo period."
"This is the Accepted version of the following article: The phytotherapeutic agent, eviprostat, suppresses stromal proliferation and inflammation even after establishment of nonbacterial prostatitis in the rat prostate; Urology; Volume 83 Issue 3 (2014) Pages 528-534; doi: 10.1016/j.urology.2013.11.033, which has been published in final form at https://doi.org/10.1016/j.urology.2013.11.033 . "
Text Version
ETD
Grant ID
博甲第594号
Grant Date
2014-06-25
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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