Overexpression of G protein-coupled receptor 87 correlates with poorer tumor differentiation and higher tumor proliferation in non-small-cell lung cancer

( Max 2000 Items )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27639
Title
Overexpression of G protein-coupled receptor 87 correlates with poorer tumor differentiation and higher tumor proliferation in non-small-cell lung cancer
File
Description

Abstract

G protein-coupled receptor 87 (GPR87) is a newly deorphanized member of the transmembrane G protein-coupled receptor family. Recently, GPR87 was suggested to contribute to the viability of human tumor cells and overexpression of GPR87 mRNA was detected in a number of malignant tumors, including lung cancer. We performed a retrospective study of GPR87 expression in association with clinical characteristics and biological markers in non-small-cell lung cancer (NSCLC). We investigated a total of 123 patients with NSCLC who underwent surgery between 1999 and 2004 (58 adenocarcinomas, 53 squamous cell carcinomas and 12 others). Immunohistochemistry was used to evaluate the intratumoral expression of GPR87 and the Ki-67 proliferation index. The TUNEL method was also used to investigate tumor apoptosis. A total of 63 tumors (51.2%) were found to be GPR87-positive. These tumors were more frequently encountered among squamous cell carcinomas rather than among adenocarcinomas (62.3 vs. 43.1%, respectively; P=0.044) and were significantly more frequently poorly and moderately differentiated rather than well differentiated (P=0.029). Moreover, the Ki-67 index was significantly higher in GPR87-positive compared to GPR87-negative tumors (57.0 vs. 40.0%, respectively; P=0.002). The overall survival was significantly worse for patients with GPR87-positive compared to those with GPR87-negative tumors (P=0.029). The Cox regression analyses also demonstrated that the GPR87 status was a significant prognostic factor for NSCLC patients [hazard ratio=2.053; P=0.018). The present study demonstrated that in NSCLC, the overexpression of GPR87 is significantly associated with poorer differentiation and higher proliferation. During the progression of NSCLC, GPR87 overexpression may be associated with the acquisition of a more aggressive phenotype and, therefore, is a potentially useful target for prognostication and treatment.

KEYWORDS:

G protein-coupled receptor 87; differentiation; non-small-cell lung cancer; prognostic factor; proliferation; survival

(医博甲600号)

Author
著者 新居 和人
著者(ヨミ) ニイ カズヒト
著者(別表記) Nii Kazuhoto
Publication Title
Molecular and Clinical Oncology
Publication Title Alternative
Mol Clin Oncol.
Volume
2
Issue
4
Start Page
539
End Page
544
Publisher
Spandidos Publications
Published Date
2014-05-14
ISSN
2049-9450
NCID
AA12610944
PMID
24940491
DOI
10.3892/mco.2014.292
Resource Type
Thesis or Dissertation
Language
eng
Relation
PMCID: PMC4051562
Resource URL
https://doi.org/10.3892/mco.2014.292
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051562/
Rights
Copyright © Spandidos Publications 2014.
"This is the Publisher's Version of the following article: Overexpression of G protein-coupled receptor 87 correlates with poorer tumor differentiation and higher tumor proliferation in non-small-cell lung cancer; Molecular and Clinical Oncology; Volume 2 Issue 4 (2014) Pages: 539-544; doi: 10.3892/mco.2014.292, which has been published in final form at https://doi.org/10.3892/mco.2014.292 . "
Text Version
ETD
Grant ID
博甲第600号
Grant Date
2015-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.