Ameliorative effects of yokukansan on behavioral deficits in a gerbil model of global cerebral ischemia

( Max 2000 Items )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27641
Title
Ameliorative effects of yokukansan on behavioral deficits in a gerbil model of global cerebral ischemia
File
Description

Abstract

The aim of this study was to investigate the neuroprotective effects of yokukansan, a traditional Kampo medicine, on the behavioral dysfunction induced by cerebral ischemia/reperfusion injury in gerbils. Gerbils were treated with yokukasan by oral gavage for 30 days, once per day, until the day before induction of ischemia, which was induced by occluding the bilateral common carotid artery for 5 min. The effects of yokukansan (50, 100 and 300 mg/kg) were examined by measuring neuronal damage and behavioral deficits (locomotor activity, 8-arm radial maze task). The anti-inflammatory and anti-oxidant properties of yokukansan were also examined. Administration of yokukansan at 300 mg/kg significantly reduced hippocampal neuronal death after brain ischemia, inhibited the ischemia-induced inflammatory response and DNA oxidative damage. Yokukansan also reduced ischemia-induced locomotor hyperactivity and improved memory impairment. These findings suggest that yokukansan can inhibit the inflammatory response, oxidative damage and subsequent neuronal death induced by cerebral ischemia/reperfusion injury, and also can contribute to improvement in neurological deficits following such injury.

KEYWORDS:

Behavior; Cerebral ischemia; Gerbil; Inflammation; Kampo medicine; Oxidative stress; Yokukansan

(医博甲602)

Author
著者 劉 亜南
著者(ヨミ) リュウ アナン
著者(別表記) Liu Yanan
Publication Title
Brain Research
Publication Title Alternative
Brain Res.
Volume
1543
Start Page
300
End Page
307
Publisher
Elsevier
Published Date
2013-11-19
ISSN
0006-8993
NCID
AA1152177X
PMID
24269335
DOI
10.1016/j.brainres.2013.11.015
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1016/j.brainres.2013.11.015
Text Version
none
Grant ID
博甲第602号
Grant Date
2015-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.