Effect of the Renin Inhibitor Aliskiren against Retinal Ischemia-reperfusion Injury

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27645
Title
Effect of the Renin Inhibitor Aliskiren against Retinal Ischemia-reperfusion Injury
File
Description

Abstract

The purpose of this study was to investigate the effect of the renin inhibitor, aliskiren, on retinal ischemia-reperfusion injury. Retinal ischemia was induced by increasing intraocular pressure to 130 mmHg. At 7 days after ischemia, retinal damage was evaluated by measuring the retinal thickness and the number of retinal ganglion cells. Western blot was used to measure changes in the (pro)renin receptor expression. Retinal mRNA expressions of prorenin, angiotensinogen and angiotensin II type 1 receptor (AT1-R) were measured by real-time polymerase chain reaction. Rats were treated with the renin inhibitor, aliskiren. Although the number of retinal ganglion cells and the inner retinal thickness were significantly decreased at 7 days after ischemia, treatment with aliskiren significantly inhibited retinal ischemic injury. Administration of aliskiren increased mRNA expression of prorenin in the retina at 3 h after the reperfusion. The expression of the (pro)renin receptor was not changed after ischemia-reperfusion injury with or without aliskiren. Although there was an increase in the retinal expression of AT1-R at 3 h after the reperfusion, aliskiren administration suppressed this expression. A renin inhibitor attenuated subsequent ischemic damage in the rat retina via the inhibition of the prorenin-induced angiotensin generation.

KEYWORDS:

(pro)renin; aliskiren; angiotensin II type 1 receptor (AT1-R); angiotensinogen; renin; renin-angiotensin-aldosterone-system; retinal ischemia

(医博甲606)

Author
著者 請川 香里
著者(ヨミ) ウケガワ カオリ
著者(別表記) Ukegawa Kaori
Publication Title
Experimental Eye Research
Publication Title Alternative
Exp Eye Res.
Volume
122
Start Page
110
End Page
118
Publisher
International Society for Eye Research
Academic Press
Elsevier
Published Date
2014-04-05
ISSN
0014-4835
NCID
AA00641055
PMID
24709336
DOI
10.1016/j.exer.2014.03.011
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1016/j.exer.2014.03.011
Text Version
none
Grant ID
博甲第606号
Grant Date
2015-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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