Rat strain differences in levels and effects of chronic inflammation due to intratracheal instillation of quartz on lung tumorigenesis induced by DHPN

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27646
Title
Rat strain differences in levels and effects of chronic inflammation due to intratracheal instillation of quartz on lung tumorigenesis induced by DHPN
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Description

Abstract

Chronic inflammatory effects of single intratracheal instillation (i.t.) of quartz on rat lung tumorigenesis were examined using 4 different animal models. At first, in order to determine an appropriate dose of quartz i.t. to promote lung tumorigenesis, F344 male rats were administrated single 0, 0.5, 1, 2 or 4 mg quartz/rat after initiation by N-bis(2-hydroxypropyl) nitrosamine (DHPN). Further studies were performed to examine strain differences of the effects of chronic inflammation caused by quartz i.t. in 3 strains of rat, i.e. F344, Wistar-Hannover and SD. Each was instilled with 2mg quartz/rat after DHPN administration and sacrificed in week 24. In addition, strain differences in generation of inflammation were determined at days 1 and 28. Finally, for determination of long-term effects period, F344 and Wistar-Hannover rats were similarly treated, but the experiment was terminated at week 52. In F344 rats, the tumor areas in DHPN treated groups showed a tendency to increase along with the dose of quartz. F344 rats demonstrated the highest and Wistar-Hannover rats the lowest sensitivity to quartz in acute and chronic phases in the 3 strains. In 52 week, in F344 rats, the multiplicity of tumors and the serum concentration of IL-6 in the group treated with DHPN and quartz were significantly increased. The present experiments indicated that chronic inflammation due to quartz instillation exerted promoting effects on lung carcinogenesis in F344, SD and Wistar-Hannover rats. The strain differences in tumor promotion appeared to correlate with inflammatory reactions to quartz and increase of IL-6.

KEYWORDS:

Chronic inflammation; DHPN; Lung rat tumorigenesis; Quartz; Strain difference

(医博甲607)

Author
著者 中野 裕子
著者(ヨミ) ナカノ ユウコ
著者(別表記) Nakano Yuko
Publication Title
Experimental and Toxicologic Pathology
Publication Title Alternative
Exp Toxicol Pathol.
Volume
66
Issue
8
Start Page
391
End Page
340
Publisher
Elsevier
Urban and Fischer
Published Date
2014-07-08
ISSN
0940-2993
NCID
AA10835750
PMID
25024166
DOI
10.1016/j.etp.2014.06.002
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1016/j.etp.2014.06.002
Text Version
none
Grant ID
博甲第607号
Grant Date
2015-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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