Prognostic Factors in Patients with Hepatocellular Carcinoma Refractory or Intolerant to Sorafenib

( Max 2000 Items )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27649
Title
Prognostic Factors in Patients with Hepatocellular Carcinoma Refractory or Intolerant to Sorafenib
File
Description

Abstract
OBJECTIVE:

The aim of this study was to identify the prognostic factors in patients with advanced hepatocellular carcinoma (HCC) who are refractory or intolerant to sorafenib and to exclude unsuitable candidates from subsequent therapy.
METHODS:

The study cohort consisted of 111 patients who had discontinued sorafenib therapy. Uni- and multivariate analyses were conducted to identify the prognostic factors for survival after discontinuation of sorafenib therapy.
RESULTS:

The median age of the patients was 70 years, and 96 of them (86%) were male. The Eastern Cooperative Oncology Group performance status was 0-1 in 94 patients (85%). Forty patients (36%) were classified as Child-Pugh class A and 57 (51%) as Child-Pugh class B. The median survival time after discontinuation of sorafenib therapy was 146 days. Hepatitis C viral antibody negativity, presence of ascites, absence of a history of previous treatment excluding sorafenib, elevated serum total bilirubin level, and elevated serum α-fetoprotein level were identified as the independent unfavorable prognostic factors by multivariate analysis. The median survival time of the patients with 4 or 5 unfavorable prognostic factors was 59 days.
CONCLUSIONS:

We should judge the indication of any subsequent therapy carefully in patients with 4 or 5 of the aforementioned factors.

(医博甲610)

Author
著者 奥山 浩之
著者(ヨミ) オクヤマ ヒロユキ
著者(別表記) Okuyama Hiroyuki
Publication Title
Oncology
Publication Title Alternative
Oncology.
Volume
88
Issue
4
Start Page
241
End Page
246
Publisher
Karger Publishers
Published Date
2014-12-11
ISSN
0030-2414
NCID
AA00764146
PMID
25503567
DOI
10.1159/000369351
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1159/000369351
Text Version
none
Grant ID
博甲第610号
Grant Date
2015-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.