Immunohistochemically detected expression of p27(Kip1)and Skp2 predicts survival in patients with intrahepatic cholangiocarcinomas

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27650
Title
Immunohistochemically detected expression of p27(Kip1)and Skp2 predicts survival in patients with intrahepatic cholangiocarcinomas
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Description

Abstract

In intrahepatic cholangiocarcinomas (ICCs), the prognostic significance of p27(Kip1), a cyclin-dependent kinase inhibitor, remains controversial, and there have been no studies of degradation pathway associated proteins, S-phase kinase-interacting protein (Skp2), and Jun activation domain-binding protein-1 (Jab1). In the present study of 74 patients with ICC-mass forming type (ICC-MF) undergoing radical surgery, we determined immunohistochemical expression of p27(Kip1), Skp2, and Jab1 and examined relationships with clinicopathologic findings and patient survival. On the basis of the average of labeling indices, we set cutoff values to define high and low expressors and divided the cases into two groups. A statistically significant correlation was found between low p27(Kip1) expression and lymph node metastasis (P = .009). Patient survival in the low p27(Kip1) expression group (n = 25) was also significantly worse than that in the high p27(Kip1) expression group (n = 49, P = .0007). A significant inverse correlation was found between p27(Kip1) and Skp2 expression (P = .016). High Skp2 expression (n = 36) was significantly associated with poor prognosis (P = .0046). High Jab1 expression was observed in 32 cases, but there was no statistically significant relationship with clinicopathologic findings or patient survival. The multivariate analysis revealed that low p27(Kip1) and high Skp2 expression are independent and significant factors of poor prognosis. The results suggest that low p27(Kip1) and high Skp2 expression are associated with aggressive tumor behavior, and these cell-cycle regulators are useful markers to predict outcome of patients with ICC-MF.

(医博甲611)

Author
著者 橋本 希
著者(ヨミ) ハシモト ノゾミ
著者(別表記) Hashimoto Nozomi
Publication Title
Annals of Surgical Oncology
Publication Title Alternative
Ann Surg Oncol.
Volume
16
Issue
2
Start Page
395
End Page
403
Publisher
American Society of Breast Surgeons
Springer (part of Springer Nature)
Published Date
2008-11-26
ISSN
1068-9265
NCID
AA11016573
PMID
19034576
DOI
10.1245/s10434-008-0236-0
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1245/s10434-008-0236-0
Text Version
none
Grant ID
博甲第611号
Grant Date
2015-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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