Vimentin regulates the invasiveness and is a poor prognostic marker in non-small cell lung cancer

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27851
Title
Vimentin regulates the invasiveness and is a poor prognostic marker in non-small cell lung cancer
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Description

Abstract
BACKGROUND:

Lung cancer cells often express vimentin. However, the function of vimentin in lung cancer cells has not been fully evaluated.
MATERIALS AND METHODS:

We evaluated the association between vimentin expression in resected non-small cell lung cancer (NSCLC) specimens and prognosis. Short-interfering RNA targeting vimentin and establishment of an invasive cell line by repeated selection of invasive cells using a Matrigel membrane invasion chamber system (MICS) were performed. MICS was used to reveal the relationship between invasiveness and vimentin.
RESULTS:

Vimentin positivity was significantly associated with a poor prognosis and was significantly lower in squamous cell carcinoma than in adenocarcinoma. In in vitro experiments, silencing of vimentin reduced invasiveness. Highly invasive cell lines exhibited higher expression of vimentin than did parental cells, and invasive ability was reduced by knockdown of vimentin.
CONCLUSION:

Vimentin expression is associated with prognosis via alteration of the invasive ability of NSCLC cells.

KEYWORDS:

Lung cancer; invasion; prognosis; vimentin

Author
著者 田所 明
著者(ヨミ) タドコロ  アキラ
著者(別表記)
Publication Title
Anticancer Research
Volume
36
Issue
4
Start Page
1545
End Page
1551
Publisher
International Institute of Anticancer Research
Published Date
2016-04-01
ISSN
0250-7005
PMID
27069130
Resource Type
Thesis or Dissertation
Language
eng
Text Version
ETD
Grant ID
博甲第639号
Grant Date
2016-6-28
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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