Developmental characteristics of urinary coproporphyrin I/(I +III) ratio

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27852
Title
Developmental characteristics of urinary coproporphyrin I/(I +III) ratio
File
Description

Abstract
BACKGROUND:

The ratio of urinary coproporphyrin (UCP) I to total urinary coproporphyrin I and III [UCP {I/(I + III)]] serves as a biomarker of the ATP-binding cassette, sub-family C, member 2 (ABCC2) function. The aim of this study was to clarify the characteristics of the developmental pattern of UCP [I/(I + III)] in order to estimate ABCC2 function in children, especially in the neonatal period, by measuring it throughout the entirety of childhood.
METHOD:

Measurement of UCP [I/(I + III)] was done high-performance liquid chromatography, using urine samples collected from children from 1 day to 15 years old, involving one sample per child. Urine samples from children with liver and kidney disease and urinary tract infection were excluded.
RESULTS:

UCP [I/(I + III)] varied widely in infants younger than 6 months old, and was ≥0.3 in 80% of the infants. In contrast, it decreased to <0.30, the lowest, at 1-2 years old. In the 0-6-month-old group, no significant correlation was noted between postnatal age and UCP [I/(I + III)], but a moderate inverse correlation was noted between corrected gestational age and UCP [I/(I + III)].
CONCLUSION:

UCP [I/(I + III)] is inversely correlated with corrected gestational age and is lowest at 1-2 years old. This suggests that ABCC2 activity is correlated with corrected gestational age and is highest at 1-2 years old.

KEYWORDS:

ATP-binding cassette, sub-family C, member 2; bilirubin; children; coproporphyrin; high-performance liquid chromatography

(医博甲640)

Author
著者 國方 淳
著者(ヨミ) クニカタ ジュン
著者(別表記) Kunikata Jun
Publication Title
Pediatrics International
Publication Title Alternative
Pediatr Int.
Volume
58
Issue
10
Start Page
974
End Page
978
Publisher
Japan Pediatric Society
Wiley
Publisher Aalternative
日本小児科学会
Published Date
2016-01-21
ISSN
1328-8067
NCID
AA11320483
PMID
26920082
DOI
10.1111/ped.12965
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1111/ped.12965
Relation(isVersionOf)
Publisher's Version
Text Version
none
Grant ID
博甲第640号
Grant Date
2016-06-28
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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