D-allose attenuates overexpression of inflammatory cytokines after cerebral ischemia/reperfusion injury in gerbil

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27869
Title
D-allose attenuates overexpression of inflammatory cytokines after cerebral ischemia/reperfusion injury in gerbil
File
Description

Abstract
BACKGROUND:

The present study investigates the effects of d-allose, a rare sugar, on the inflammatory response after transient forebrain ischemia in the gerbil and whether it reduces oxidative stress (8-hydroxyl-2'-deoxyguanosine levels) and behavioral deficits.
METHODS:

Transient forebrain ischemia was induced by occlusion of the bilateral common carotid arteries for 5 minutes. d-Allose was intraperitoneally injected immediately after ischemia (400 mg/kg). Inflammatory cytokines and oxidative damage in the hippocampus and behavioral deficits were examined 3 days after ischemia.
RESULTS:

d-Allose administration reduced ischemia-induced cytokine production, oxidative stress, and behavioral deficits (motor and memory related).
CONCLUSIONS:

The present results suggest that d-allose reduces brain injury after transient global ischemia by suppressing inflammation as well as by inhibiting oxidative stress.

KEYWORDS:

Ischemia; cytokines; d-allose; hyperactivity; inflammation; oxidation; reperfusion

(医博甲643)

Author
著者 篠原 奈都代
著者(ヨミ) シノハラ ナツヨ
著者(別表記) Shinohara Natsuyo
Publication Title
Journal of Stroke and Cerebrovascular Diseases
Publication Title Alternative
J Stroke Cerebrovasc Dis.
Volume
25
Issue
9
Start Page
2184
End Page
2188
Publisher
Japan Stroke Society
National Stroke Association
Elsevier
Publisher Aalternative
日本脳卒中学会
Published Date
2016 Jun 21 [EPub]
ISSN
1052-3057
NCID
AA10780852
PMID
27342700
DOI
10.1016/j.jstrokecerebrovasdis.2016.01.030
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.01.030
Relation(isVersionOf)
Publisher's Version
Rights
This article is provided in the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (CC-BY-NC-ND 4.0) .https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
Publisher's Version DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.01.030
Text Version
ETD
Grant ID
博甲第643号
Grant Date
2016-06-28
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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