Remote Ischemic Preconditioning of the Femoral Artery and Vein does not Protect against Renal Ischemia/Reperfusion-induced Injury in Anesthetized Mice

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27878
Title
Remote Ischemic Preconditioning of the Femoral Artery and Vein does not Protect against Renal Ischemia/Reperfusion-induced Injury in Anesthetized Mice
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Description

Abstract
Multiple cycles of short Ischemia/Reperfusion (I/R) of the limb(s) is hypothesized to be a potential therapeutic strategy against I/R-induced injury of the peripheral organs, so-called Remote Ischemic Preconditioning (RIPC). Our aim is to examine the efficacy of experimental RIPC for renal I/R-induced injury in mice for the future further analysis. We investigated the effects of seven different RIPC protocols involving the right femoral artery and vein of either isoflurane- or pentobarbital-anesthetized mice. However, none of these protocols protected the kidney against I/R injury. In conclusion, RIPC of a direct clamping of femoral artery and vein gave no protection against renal I/R-induced injury in anesthetized mice.

Keywords: Ischemia reperfusion; Remote ischemic preconditioning; Anesthesia

(医博甲657)

Author
著者 張 一凡
著者(ヨミ) サン イーファン
著者(別表記) Zhang Yifan
Publication Title
Journal of Urology and Nephrology Open Access
Volume
2
Issue
2
Start Page
1
End Page
5
Publisher
Symbiosis Group
Published Date
2016-05-20
ISSN
2473-6430
DOI
10.15226/2473-6430/2/2/00110
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.15226/2473-6430/2/2/00110
Relation(isVersionOf)
Publisher's Version.
Text Version
ETD
Grant ID
博甲第657号
Grant Date
2017-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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