Relationship between dose-volume parameters and pulmonary complications after neoadjuvant chemoradiotherapy followed by surgery for lung cancer

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27880
Title
Relationship between dose-volume parameters and pulmonary complications after neoadjuvant chemoradiotherapy followed by surgery for lung cancer
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Description

Abstract
PURPOSE:

This study evaluated the relationship between dose-volume histogram (DVH) parameters and pulmonary complications after neoadjuvant chemoradiotherapy (NACRT) followed by surgery for lung cancer. We also examined a new DVH parameter, because the unresected lung should be more spared than the later resected lung.
PATIENTS AND METHODS:

Data from 43 non-small cell lung cancer patients were retrospectively analyzed. The DVH parameters of the lung were calculated from the total bilateral lung volume minus (1) the gross tumor volume (DVHg) or (2) the later resected lung volume (DVHr). Radiation pneumonitis (RP) and fistula, including bronchopleural and pulmonary fistula, were graded as the pulmonary complications. Factors affecting the incidences of grade 2 or higher RP (≥G2 RP) and fistula were analyzed.
RESULTS:

Sixteen patients (37 %) experienced ≥G2 RP and a V20 value of the total lung minus the later resected lung (V20r) ≥ 12 % was a significant factor affecting the incidence of ≥G2 RP (p = 0.032). Six patients (14 %) developed a fistula and a V35 value of the total lung minus the gross tumor (V35g) ≥ 19 % and a V40g ≥ 16 % were significant factors affecting the incidence of fistula (p = 0.002 and 0.009, respectively).
CONCLUSION:

These DVH parameters may be related to the incidences of ≥G2 RP and fistula.

KEYWORDS:

Fistula; Morbidity; Non-small cell lung cancer; Radiation pneumonitis; Toxicity

(医博甲659)

Author
著者 髙橋 重雄
著者(ヨミ) タカハシ シゲオ
著者(別表記) Takahashi Shigeo
Publication Title
Strahlentherapie und Onkologie
Publication Title Alternative
Strahlenther Onkol.
Volume
192
Issue
9
Start Page
658
End Page
667
Publisher
Urban and Vogel
Springer
Published Date
2016-07-14
ISSN
0179-7158
NCID
AA10703079
PMID
27418130
DOI
10.1007/s00066-016-1021-9
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1007/s00066-016-1021-9
Relation(isVersionOf)
Publisher's Version.
Text Version
none
Grant ID
博甲第659号
Grant Date
2017-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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