Galectin -9: An anticancer molecule for gallbladder carcinoma

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27881
Title
Galectin -9: An anticancer molecule for gallbladder carcinoma
File
Description

Abstract

Gallbladder cancer (GBC) is the most common and aggressive type of biliary tract cancer. There are various histological types of GBC, and the vast majority of GBC cases are adenocarcinomas. Squamous and adenosquamous carcinomas are rare GBC subtypes that are traditionally considered to be more aggressive and to be associated with a poorer prognosis than adenocarcinoma. Galectin-9 (Gal-9), a tandem-repeat-type galectin, has been reported to induce apoptosis-mediated elimination of various cancers, including hepatocellular carcinoma, cholangiocarcinoma, and hematologic malignancies. Therefore, we investigated the antitumor effects of Gal-9 on GBC in vitro and in vivo. In our in vitro experiments, Gal-9 suppressed cell proliferation in various GBC cell lines but not in the OCUG-1 cell line, which represents a poorly differentiated type of adenosquamous carcinoma. Gal-9 induced the apoptosis of Gal-9-sensitive GBC cells by increasing the levels of caspase-cleaved keratin 18 and phosphorylated p53. However, Gal-9 did not affect the expression of various cell cycle-related proteins. In addition, Gal-9 suppressed tumor growth by implanted human GBC cells in a xenograft model. Furthermore, Gal-9 induced the phosphorylation of the Ephrin type-B receptor, and the microRNA (miRNA) expression profile was markedly altered by Gal-9. Based on these results, various miRNAs might contribute to the suppression of tumor growth. Our data reveal that Gal-9 suppresses the growth of GBC, possibly by inducing apoptosis and altering miRNA expression. Thus, Gal-9 might serve as a therapeutic agent for the treatment of GBC.

(医博甲660)

Author
著者 田所 智子
著者(ヨミ) タドコロ トモコ
著者(別表記) Tadokoro Tomoko
Publication Title
International Journal of Oncology
Publication Title Alternative
Int J Oncol.
Volume
48
Issue
3
Start Page
1165
End Page
1174
Publisher
Spandidos Publications
Published Date
2016-01-19
ISSN
1019-6439
NCID
AA10992511
PMID
26797414
DOI
10.3892/ijo.2016.3347
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.3892/ijo.2016.3347
Relation(isVersionOf)
Publisher's Version.
Text Version
ETD
Grant ID
博甲第660号
Grant Date
2017-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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