Galectin -9: An anticancer molecule for gallbladder carcinoma

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27881
タイトル
Galectin -9: An anticancer molecule for gallbladder carcinoma
ファイル
内容記述

Abstract

Gallbladder cancer (GBC) is the most common and aggressive type of biliary tract cancer. There are various histological types of GBC, and the vast majority of GBC cases are adenocarcinomas. Squamous and adenosquamous carcinomas are rare GBC subtypes that are traditionally considered to be more aggressive and to be associated with a poorer prognosis than adenocarcinoma. Galectin-9 (Gal-9), a tandem-repeat-type galectin, has been reported to induce apoptosis-mediated elimination of various cancers, including hepatocellular carcinoma, cholangiocarcinoma, and hematologic malignancies. Therefore, we investigated the antitumor effects of Gal-9 on GBC in vitro and in vivo. In our in vitro experiments, Gal-9 suppressed cell proliferation in various GBC cell lines but not in the OCUG-1 cell line, which represents a poorly differentiated type of adenosquamous carcinoma. Gal-9 induced the apoptosis of Gal-9-sensitive GBC cells by increasing the levels of caspase-cleaved keratin 18 and phosphorylated p53. However, Gal-9 did not affect the expression of various cell cycle-related proteins. In addition, Gal-9 suppressed tumor growth by implanted human GBC cells in a xenograft model. Furthermore, Gal-9 induced the phosphorylation of the Ephrin type-B receptor, and the microRNA (miRNA) expression profile was markedly altered by Gal-9. Based on these results, various miRNAs might contribute to the suppression of tumor growth. Our data reveal that Gal-9 suppresses the growth of GBC, possibly by inducing apoptosis and altering miRNA expression. Thus, Gal-9 might serve as a therapeutic agent for the treatment of GBC.

(医博甲660)

著者
著者 田所 智子
著者(ヨミ) タドコロ トモコ
著者(別表記) Tadokoro Tomoko
掲載誌
International Journal of Oncology
掲載誌(別表記)
Int J Oncol.
48
3
開始ページ
1165
終了ページ
1174
出版者
Spandidos Publications
出版年月日
2016-01-19
ISSN
1019-6439
NCID
AA10992511
PMID
26797414
DOI
10.3892/ijo.2016.3347
資料タイプ
学位論文
言語
英語
関連情報URL
https://doi.org/10.3892/ijo.2016.3347
関連情報(isVersionOf)
Publisher's Version.
博士論文(全文を含む)
学位授与番号
博甲第660号
学位授与年月日
2017-03-24
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
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