Intratumoral heterogeneity of 18F-FLT uptake predicts proliferation and survival in patients with newly diagnosed gliomas

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27883
タイトル
Intratumoral heterogeneity of 18F-FLT uptake predicts proliferation and survival in patients with newly diagnosed gliomas
ファイル
内容記述

Abstract
BACKGROUND:

The nucleoside analog 3'-deoxy-3'-18F-fluorothymidine (FLT) has been investigated for evaluating tumor proliferating activity in brain tumors. We evaluated FLT uptake heterogeneity using textural features from the histogram analysis in patients with newly diagnosed gliomas and examined correlation of the results with proliferative activity and patient prognosis, in comparison with the conventional PET parameters.
METHODS:

FLT PET was investigated in 37 patients with newly diagnosed gliomas. The conventional parameters [tumor-to-contralateral normal brain tissue (T/N) ratio and metabolic tumor volume (MTV)] and textural parameters (standard deviation, skewness, kurtosis, entropy, and uniformity) were derived from FLT PET images. Linear regression analysis was used to compare PET parameters and the proliferative activity as indicated by the Ki-67 index. The associations between parameters and overall survival (OS) were tested by Cox regression analysis.
RESULTS:

Median OS was 662 days. For the conventional parameters, linear regression analysis indicated a significant correlation between T/N ratio and Ki-67 index (p = 0.02) and MTV and Ki-67 index (p = 0.02). Among textural parameters, linear regression analysis indicated a significant correlation for kurtosis (p = 0.003), entropy (p < 0.001), and uniformity (p < 0.001) as compared to Ki-67 index, exceeding those of the conventional parameters. The results of univariate analysis suggested that skewness and kurtosis were associated with OS (p = 0.03 and 0.02, respectively). Mean survival for patients with skewness values less than 0.65 was 1462 days, compared with 917 days for those with values greater than 0.65 (p = 0.02). Mean survival for patients with kurtosis values less than 6.16 was 1616 days, compared with 882 days for those with values greater than 6.16 (p = 0.006).
CONCLUSIONS:

Based on the results of this preliminary study in a small patient population, textural features reflecting heterogeneity on FLT PET images seem to be useful for the assessment of proliferation and for the potential prediction of survival in newly diagnosed gliomas.

KEYWORDS:

18F-FLT; Glioma; Heterogeneity; PET; Texture

(医博甲662)

著者
著者 三田村 克哉
著者(ヨミ) ミタムラ カツヤ
著者(別表記) Mitamura Katsuya
掲載誌
Annals of Nuclear Medicine
掲載誌(別表記)
Ann Nucl Med.
31
1
開始ページ
46
終了ページ
52
出版者
Japanese Society of Nuclear Medicine
Springer
出版者(別表記)
日本核医学会
出版年月日
2016-09-29
ISSN
0914-7187
NCID
AA10708017
PMID
27686469
DOI
10.1007/s12149-016-1129-0
資料タイプ
学位論文
言語
英語
関連情報URL
https://doi.org/10.1007/s12149-016-1129-0
関連情報(isVersionOf)
Publisher's Version.
博士論文(全文を含む)
学位授与番号
博甲第662号
学位授与年月日
2017-03-24
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
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