Serum microRNA expression profiling in patients with multiple system atrophy

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28443
Title
Serum microRNA expression profiling in patients with multiple system atrophy
File
Description

Abstract

Multiple system atrophy (MSA) is a sporadic neurodegenerative disease that is pathologically characterized by α‑synuclein positive glial cytoplasmic inclusions in oligodendrocytes. The clinical diagnosis of MSA is often challenging as there are no established biomarkers and diagnoses are now based on clinical findings alone. At present, the etiology and pathogenesis of MSA are unclear. It has been reported that dysregulation of microRNA (miRNA/miR) serves an important role in neurodegenerative disorders including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. The miRNA profile of patients with MSA remains to be established. The present study investigated the serum miRNA expression level of 10 patients with MSA, using microarray chips including 668 miRNAs. It was identified that 50 miRNAs were significantly upregulated and 17 miRNAs were significantly downregulated in the serum of the patients with MSA. The most upregulated miRNA was miR‑16, which may induce the accumulation of α‑synuclein. The target genes of some miRNAs upregulated in MSA (including miR‑17, 20a, 24, 25, 30d and 451) were associated with autophagy‑associated molecules. The present study concluded that the expression pattern of miRNAs may be a clinical biomarker for MSA and targeting these miRNAs may provide a novel treatment for MSA.

(医博甲672)

Author
著者 久米 広大
著者(ヨミ) クメ コウダイ
著者(別表記) Kume Kodai
Publication Title
Molecular Medicine Reports
Publication Title Alternative
Mol Med Rep.
Volume
17
Issue
1
Start Page
852
End Page
860
Publisher
Spandidos Publications
Published Date
2017-11-07
ISSN
1791-2997
PMID
29115515
DOI
10.3892/mmr.2017.7995
Resource Type
Thesis or Dissertation
Language
eng
Relation
PMCID: PMC5780164
Resource URL
出版社版DOIリンク(URL): https://doi.org/10.3892/mmr.2017.7995
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780164/
Rights
Copyright: © Kume et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
DOI: https://doi.org/10.3892/mmr.2017.7995
Text Version
ETD
Grant ID
博甲第672号
Grant Date
2017-06-22
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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