Effects of sodium-glucose cotransporter 2 inhibitors on urinary excretion of intact and total angiotensinogen in patients with type 2 diabetes

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28445
Title
Effects of sodium-glucose cotransporter 2 inhibitors on urinary excretion of intact and total angiotensinogen in patients with type 2 diabetes
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Description

Abstract

We conducted a descriptive case study to examine the effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on urinary angiotensinogen excretion, which represents the function of the intrarenal renin-angiotensin system, in patients with type 2 diabetes. An SGLT2 inhibitor (canagliflozin 100 mg/day, ipragliflozin 25 mg/day, dapagliflozin 5 mg/day, luseogliflozin 2.5 mg/day or tofogliflozin 20 mg/day) was administered for 1 month (n=9). ELISA kits were used to measure both urinary intact and total angiotensinogen levels. Treatment with SGLT2 inhibitors significantly decreased hemoglobin A1c, body weight, systolic blood pressure and diastolic blood pressure (8.5±1.3 to 7.5%±1.0%, 82.5±20.2 to 80.6±20.9 kg, 143±8 to 128±14 mm Hg, 78±10 to 67±9 mm Hg, p<0.05, respectively), while urinary albumin/creatinine ratio was not significantly changed (58.6±58.9 to 29.2±60.7 mg/g, p=0.16). Both total urinary angiotensinogen/creatinine ratio and intact urinary angiotensinogen/creatinine ratio tended to decrease after administration of SGLT2 inhibitors. However, these changes were not significant (p=0.19 and p=0.08, respectively). These data suggest that treatment with SGLT2 inhibitors does not activate the intrarenal renin-angiotensin system in patients with type 2 diabetes.

KEYWORDS:

SGLT2 inhibitor; blood pressure; type 2 diabetes; urinary albumin; urinary angiotensinogen

(医博甲674)

Author
著者 吉本 卓生
著者(ヨミ) ヨシモト タクミ
著者(別表記) Yoshimoto Takumi
Publication Title
Journal of Investigative Medicine
Publication Title Alternative
J Investig Med.
Volume
65
Issue
7
Start Page
1057
End Page
1061
Publisher
American Federation for Medical Research
Lippincott, Williams & Wilkins
Published Date
2017-06-08
ISSN
1081-5589
NCID
AA11166929
PMID
28596160
DOI
10.1136/jim-2017-000445
Resource Type
Thesis or Dissertation
Language
eng
Relation
PMCID: PMC5812257
出版社版DOIリンク(URL): https://doi.org/10.1136/jim-2017-000445
Resource URL
https://doi.org/10.1136/jim-2017-000445
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812257/
Rights
Copyright © American Federation for Medical Research (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
DOI: https://doi.org/10.1136/jim-2017-000445
Text Version
ETD
Grant ID
博甲第674号
Grant Date
2017-09-27
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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