Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28448
Title
Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets
File
Description

Abstract
BACKGROUND:

Although liver can be injured under the hypoxic-ischemic encephalopathy (HIE) condition, there is currently no histopathological evidence. Therapeutic hypothermia is used to protect the brain; however, the therapeutic potential for concomitant liver injury is unknown.
OBJECTIVES:

This study aimed to histopathologically prove HIE-associated liver injury and to investigate the influence of therapeutic hypothermia in a newborn piglet HIE model.
METHODS:

Eighteen newborn piglets were divided into 3 groups: control (n = 4), HIE (n = 8), and therapeutic hypothermia (n = 6) groups. The hypoxic insult was induced by decreasing the fraction of inspiratory oxygen from 21 to 2-4% over 40 min while monitoring cerebral blood volume and cerebral hemoglobin oxygen saturation. For therapeutic hypothermia, whole-body cooling at 33-34°C was administered for 24 h after the hypoxic insult. We hematologically and histopathologically investigated the liver injury in all groups.
RESULTS:

Alanine transaminase and lactate dehydrogenase levels in the HIE group were significantly elevated compared with those in the control group. Micro-lipid droplet accumulation in the periportal zone, but not in the perivenous zone, was significantly greater in the HIE group than in the control group and significantly smaller in the therapeutic hypothermia group than in the HIE group.
CONCLUSIONS:

We demonstrated that micro-lipid droplet accumulation in the cytoplasm of hepatocytes in the periportal zone occurs under the HIE condition and that this accumulation is suppressed by therapeutic hypothermia.

Keywords: Hypoxic-ischemic encephalopathyHypoxiaLiver injuryTherapeutic hypothermiaLipid droplets

(医博甲677)

Author
著者 久保 裕之
著者(ヨミ) クボ ヒロユキ
著者(別表記) Kubo Hiroyuki
Publication Title
Neonatology
Publication Title Alternative
Neonatology.
Volume
111
Issue
3
Start Page
203
End Page
210
Publisher
Karger Publishers
Published Date
2016-11-15
ISSN
1661-7800
NCID
AA12189602
PMID
27842320
DOI
10.1159/000450721
Resource Type
Thesis or Dissertation
Language
eng
Relation
出版社版DOIリンク(URL): https://doi.org/10.1159/000450721
Resource URL
https://doi.org/10.1159/000450721
Rights
© 2016 S. Karger AG, Basel.
"This is the Publisher's version of the following article: Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets; Neonatology; Volume 111 Number 3 (2016)) Pages 203-210; doi10.1159/000450721:, which has been published in final form at https://doi.org/10.1159/000450721 . "
doi: https://doi.org/10.1159/000450721
Text Version
ETD
Grant ID
博甲第677号
Grant Date
2018-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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