Role of the Low-Density Lipoprotein-Cholesterol/High-Density Lipoprotein-Cholesterol Ratio in Predicting Serial Changes in the Lipid Component of Coronary plaque

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28487
Title
Role of the Low-Density Lipoprotein-Cholesterol/High-Density Lipoprotein-Cholesterol Ratio in Predicting Serial Changes in the Lipid Component of Coronary plaque
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Description

Abstract
BACKGROUND:

The lipid component of coronary plaques is associated with their vulnerability. The aim of this study was to investigate which coronary risk factors were relevant in predicting serial changes in the lipid component of coronary plaques as evaluated by integrated backscatter intravascular ultrasound (IB-IVUS).Methods and Results:We enrolled 104 patients who underwent IB-IVUS-guided percutaneous coronary intervention (PCI) and were followed up with repeat IB-IVUS 6 months later. We investigated the serial changes in the plasma lipoprotein levels and the percentage of the lipid component of coronary plaques on IB-IVUS. In the multivariate linear regression analysis, the low-density lipoprotein-cholesterol/high-density lipoprotein-cholesterol (L/H) ratio independently had a significant fixed effect with the percentage of the lipid component of coronary plaques at the time of PCI. In addition, the change in the L/H ratio at the 6-month follow-up was significantly associated with that in the lipid component of coronary plaques (regression coefficient, 9.645; 95% CI: 5.814-13.475; P<0.0001); furthermore, this change was also observed in patients with an LDL-C <100 mg/dL.
CONCLUSIONS:

The L/H ratio was the most relevant parameter in predicting the lipid component of coronary plaques. Furthermore, strict management of the L/H ratio may reduce this lipid component, even in patients with an LDL-C <100 mg/dL.

KEYWORDS:

Hypercholesterolemia; Intravascular ultrasound; Lipoproteins; Vulnerable plaque

(医博甲695)

Author
著者 河上 良
著者(ヨミ) カワカミ リョウ
著者(別表記) Kawakami Ryo
Publication Title
Circulation Journal
Publication Title Alternative
Circ J.
Volume
81
Issue
10
Start Page
1439
End Page
1446
Publisher
Japanese Circulation Society
日本循環器学会
Publisher Aalternative
日本循環器学会
Published Date
2017-09-25
ISSN
1346-9843
NCID
AA11591968
PMID
28458377
DOI
10.1253/circj.CJ-16-1209
Resource Type
Thesis or Dissertation
Language
eng
Relation
出版社版DOIリンク(URL): https://doi.org/10.1253/circj.CJ-16-1209
Resource URL
https://doi.org/10.1253/circj.CJ-16-1209
Rights
Copyright © 2017 THE JAPANESE CIRCULATION SOCIETY. Free full text.
"This is the Publisher's version of the following article: Role of the Low-Density Lipoprotein-Cholesterol/High-Density Lipoprotein-Cholesterol Ratio in Predicting Serial Changes in the Lipid Component of Coronary Plaque.; Circulation Journal;Volume 81 Issue 10 (2017) Pages 1439-1446; doi: 10.1253/circj.CJ-16-1209, which has been published in final form at https://doi.org/10.1253/circj.CJ-16-1209 . "
DOI: https://doi.org/10.1253/circj.CJ-16-1209
Text Version
ETD
Grant ID
博甲第695号
Grant Date
2018-06-27
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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