Ryanodine receptors contribute to the induction of ischemic tolerance

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28492
タイトル
Ryanodine receptors contribute to the induction of ischemic tolerance
ファイル
内容記述

Ischemic tolerance (IT) is induced by a variety of insults to the brain (e.g., nonfatal ischemia, heat and hypoxia) and it provides a strong neuroprotective effect. Although the mechanisms are still not fully elucidated, Ca(2+) is regarded as a key mediator of IT. Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum membrane and are responsible for the release of Ca(2+) from intracellular stores. In brain, neuronal RyRs are thought to play a role in various neuropathological conditions, including ischemia. The purpose of the present study was to investigate the involvement of RyRs in IT. Pretreatment with a RyR antagonist, dantrolene (25mg/kg, i.p), blocked IT in a gerbil global ischemia model, while a RyR agonist, caffeine (100mg/kg, i.p), stimulated the production of IT. In vitro, using rat hippocampal cells, short-term oxygen/glucose deprivation induced preconditioning and RyR antagonists, dantrolene (50 and 100 μM) and ryanodine (100 and 200 μM) prevented it. RyR protein and mRNA levels were transiently decreased after induction of IT. These results suggest that RyRs are involved in the induction of ischemic tolerance.

著者
著者 丸山 恵美
著者(ヨミ) マルヤマ エミ
著者(別表記)
掲載誌
Brain Research Bulletin
122
開始ページ
45
終了ページ
53
出版者
Elsevier
出版年月日
2016-02-27
ISSN
0361-9230
PMID
26930163
DOI
10.1016/j.brainresbull.2016.02.018
資料タイプ
学位論文
言語
英語
関連情報
出版社版DOIリンク(URL) : https://doi.org/10.1016/j.brainresbull.2016.02.018
権利関係
エルゼビア・ジャパンに著作権ポリシーを確認した結果、リポジトリでの公開可能を確認した。 / As a result of confirming the copyright policy to Elsevier Japan, we confirmed the possibility of publishing in the repository.
博士論文(全文を含む)
学位授与番号
博甲第638号
学位授与年月日
2016-06-28
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
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