Preliminary evidence that rivastigmine-induced inhibition of serum butyrylcholinesterase activity improves behavioral symptoms in Japanese patients with Alzheimer's disease

( Max 2000 Items )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28496
Title
Preliminary evidence that rivastigmine-induced inhibition of serum butyrylcholinesterase activity improves behavioral symptoms in Japanese patients with Alzheimer's disease
File
Description

Abstract
AIM:

To investigate whether the inhibitory rate of serum butyrylcholinesterase (BuChE) activity in Japanese patients with Alzheimer's disease is correlated with cognitive function, behavioral symptoms and caregiver burden.
METHODS:

A total of 61 patients with mild to moderately severe Alzheimer's disease who were not undergoing cholinesterase enzyme inhibitor/memantine combinatorial treatment received a rivastigmine (18 mg) patch for 24 weeks. The rate of inhibition of BuChE was correlated with scores obtained on cognitive (Mini-Mental State Examination), behavioral (the Japanese version of the modified Crichton Geriatric Behavioral Rating Scale [CGBRS] and Vitality Index [VI]) and burden (the Japanese version of Zarit Burden Inventory [ZBI]) scales; and the Clinical Global Impression of Change scale.
RESULTS:

The serum BuChE activity showed a significant decrease after 24 weeks compared with baseline (P < 0.001). Overall, significant effects were found in the Mini-Mental State Examination score, VI score and modified CGBRS score. We then divided patient groups into a high inhibitory rate (≥40%) group and a low inhibitory rate (<40%) group; there were significant improvements in the Mini-Mental State Examination score, VI score and modified CGBRS score in both groups. However, favorable results were seen in cooperation, restlessness and leisure on modified CGBRS subscales in the high inhibitory rate group (P < 0.001, P = 0.007, P < 0.001, respectively), and rehabilitation and other activities on VI subscales in the high inhibitory rate group (P = 0.005) compared with those in the low inhibitory rate group.
CONCLUSIONS:

Demonstrable significant improvements in behavioral symptoms, such as low cooperation, restlessness or low activities in patients with Alzheimer's disease, were achieved on inhibition of BuChE at a rate of 40% or more. Geriatr Gerontol Int 2017; 17: 1306-1312.

KEYWORDS:

Alzheimer's disease; behavioral symptom; butyrylcholinesterase; cholinesterase inhibitor; rivastigmine

(医博乙279)

Author
著者 坂東 伸泰
著者(ヨミ) バンドウ ノブヤス
著者(別表記) Bando Nobuyasu
Publication Title
Geriatrics and Gerontology International
Publication Title Alternative
Geriatr Gerontol Int.
Volume
17
Issue
9
Start Page
1306
End Page
1312
Publisher
Japan Geriatrics Society
Wiley
Publisher Aalternative
日本老年医学会
Published Date
2016-08-21 [ePub]
ISSN
1444-1586
NCID
AA1155729X
PMID
27546156
DOI
10.1111/ggi.12865
Resource Type
Thesis or Dissertation
Language
eng
Relation
香川大学に提出された博士論文が、出版社版であった。Publisher's Versionは、出版社の著作権ポリシーに基づき、リポジトリへの掲載が不可能であったため、著者のAccepted Versionをリポジトリに掲載した。
The doctoral dissertation submitted to Kagawa University was a Publisher's version. Publisher's Version posted the author 's Accepted Version in the repository as it was impossible to publish in the repository based on the copyright policy of the publisher.
Resource URL
出版社版DOIリンク(URL) :https://doi.org/10.1111/ggi.12865
Relation(isVersionOf)
Accepted Version
Relation URL(isReplacedBy)
https://doi.org/10.1111/ggi.12865
Relation(hasVersion)
Publisher's Version
Rights
"This is the accepted version of the following article: Preliminary evidence that rivastigmine-induced inhibition of serum butyrylcholinesterase activity improves behavioral symptoms in Japanese patients with Alzheimer's disease; Geriatrics and Gerontology International;Volume 17 Number9(2017) 1306-1312; doi: 10.1111/ggi.12865, which has been published in final form athttps://doi.org/10.1111/ggi.12865 . "
Non-Commercial
12 months embargo has expired.
Text Version
ETD
Grant ID
博乙第279号
Grant Date
2017-03-03
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.