Phenotypic characterization and clinical outcome in ampullary adenocarcinoma.

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28498
タイトル
Phenotypic characterization and clinical outcome in ampullary adenocarcinoma.
ファイル
内容記述

Abstract
BACKGROUND:

Although various features of ampullary adenocarcinoma have been reported, the impact of genetic alterations and rare subtypes on clinical outcome remains unclear.
METHODS:

We determined the expression of proteins, including MUC1, MUC2, p53, p16, Smad/Dpc4, and β-catenin, and genetic mutations such as KRAS, BRAF, and GNAS mutations in 69 patients with ampullary adenocarcinoma to clarify their relationships with clinicopathological findings and subtypes.
RESULTS:

Kaplan-Meier survival analysis indicated that abnormal p53 labeling was significantly associated with a shorter overall survival. MUC1-positive and MUC2-negative expressions were significantly associated with lymphatic invasion, pancreatic invasion, lymph node metastasis, and advanced UICC stage. The KRAS mutation was significantly associated with large tumor size and pancreatic invasion. There were 35 intestinal (50%), 15 pancreatobiliary (22%), and 11 mixed subtype (16%) tumors. Patients with the mixed subtype showed significantly poor outcome. The invasiveness of the mixed subtype was similar to that of the pancreatobiliary subtype; moreover, the mixed subtype showed a high incidence of abnormal β-catenin immunolabeling (73%).
CONCLUSIONS:

Protein expression and genetic mutation are clinically associated with the characteristics of ampullary adenocarcinoma. The mixed subtype may have a distinct tumor nature as compared to other two major subtypes.

KEYWORDS:

ampullary adenocarcinoma; mixed type; p53; pathologic subtype; β-catenin

(医博甲645)

著者
著者 浅野 栄介
著者(ヨミ) アサノ エイスケ
著者(別表記) Asano Eisuke
掲載誌
Journal of Surgical Oncology
掲載誌(別表記)
J Surg Oncol.
114
1
開始ページ
119
終了ページ
127
出版者
Wiley-Liss
Wiley
出版年月日
2016-05-02
ISSN
0022-4790
NCID
AA00708010
PMID
27132476
DOI
10.1002/jso.24274
資料タイプ
学位論文
言語
英語
関連情報
香川大学に提出された博士論文が、出版社版であった。Publisher's Versionは、出版社の著作権ポリシーに基づき、リポジトリへの掲載が不可能であったため、著者のAccepted Versionをリポジトリに掲載した。 The doctoral dissertation submitted to Kagawa University was a Publisher's version. Publisher's Version posted the author 's Accepted Version in the repository as it was impossible to publish in the repository based on the copyright policy of the publisher.
関連情報(isVersionOf)
Apcepted Version.
関連情報URL(isReplacedBy)
https://doi.org/10.1002/jso.24274
関連情報(hasVersion)
Publisher's Version.
権利関係
"This is the accepted version of the following article: Phenotypic characterization and clinical outcome in ampullary adenocarcinoma; Journal of Surgical Oncology;Volume 114 Number1 (2016) 119-127; doi: 10.1002/jso.24274, which has been published in final form at https://doi.org/10.1002/jso.24274 . "
Non-Commercial
12 months embargo has expired.
博士論文(全文を含む)
学位授与番号
博甲第645号
学位授与年月日
2016-09-29
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.