Association of brain metabolites with blood lactate and glucose levels with respect to neurological outcomes after out-of-hospital cardiac arrest: a preliminary microdialysis study

( Max 2000 Items )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28500
Title
Association of brain metabolites with blood lactate and glucose levels with respect to neurological outcomes after out-of-hospital cardiac arrest: a preliminary microdialysis study
File
Description

Abstract
AIM:

Out-of-hospital cardiac arrest (OHCA) is associated with poor prognosis. Cerebral microdialysis (CMD) is an efficient sampling technique to detect neurochemical changes in brain interstitial tissue. In this retrospective study, we hypothesised that there are different CMD levels between patients with favourable and unfavourable neurological outcomes.
METHODS:

Data of patients with OHCA admitted to Kagawa University Hospital and administered therapeutic hypothermia (TH) were collected. Using a CMD probe, extracellular glucose, lactate and pyruvate levels were measured hourly along with intracranial perfusion pressure (ICP) and cerebral perfusion pressure (CPP) for the initial 72h during TH. The lactate/pyruvate (LP) ratio was calculated. Patients were divided into favourable [Glasgow-Pittsburgh cerebral performance category 1-2 at 30days after cardiac arrest] or unfavourable neurological outcome groups. CMD biochemical markers and blood lactate and glucose levels were compared between two groups.
RESULTS:

Ten patients were included. ICP was significantly higher in the unfavourable than in the favourable neurological outcome group; there were no significant differences with respect to CPP. The CMD LP ratio in the unfavourable outcome group progressively increased; significant differences were observed on days 2, 3 and 4 (p<0.01). Significant differences in blood lactate levels were observed between the groups only on day 3.5. CMD and blood glucose levels were higher in the unfavourable than in the favourable outcome group during TH.
CONCLUSION:

The association of CMD levels with long-term outcomes would be better defined in a large randomised prospective study.

KEYWORDS:

Glucose; Lactate; Microdialysis; Neurological outcome; Post cardiac arrest syndrome

(医博甲669)

Author
著者 一二三 亨
著者(ヨミ) ヒフミ トオル
著者(別表記) Hifumi Toru
Publication Title
Resuscitation
Publication Title Alternative
Resuscitation.
Volume
110
Start Page
26
End Page
31
Publisher
Elsevier
Published Date
2016-10-27
ISSN
0300-9572
NCID
AA11538761
PMID
27984152
DOI
10.1016/j.resuscitation.2016.10.013
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1016/j.resuscitation.2016.10.013
Relation(isVersionOf)
Publisher's Version.
Rights
Copyright © 2016 Elsevier Ireland Ltd.
この博士論文の本文については、次のエルゼビアの著作権ポリシーの規定により公開しています。「博士論文の場合は、エンバーゴ期間に関係なく機関リポジトリに出版社版を公開することができます。」 The text of this doctoral dissertation is published according to the following Elsevier copyright policy. "In the case of doctoral dissertations, publishers can be published in institutional repositories regardless of the Embargo period."
12 months embargo has expired.
Publisher's Version DOI: https://doi.org/10.1016/j.resuscitation.2016.10.013
Text Version
ETD
Grant ID
博甲第669号
Grant Date
2017-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.