Preference evaluation and perceived sensory comparison of fluticasone furoate and mometasone furoate intranasal sprays in allergic rhinitis

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28556
Title
Preference evaluation and perceived sensory comparison of fluticasone furoate and mometasone furoate intranasal sprays in allergic rhinitis
File
Description

Abstract
OBJECTIVE:

Intranasal corticosteroid sprays (INCSs) are commonly used for therapy of allergic rhinitis (AR). Adherence to regular use of INCSs is influenced by patient perception and preferences of products. The study objective was to compare perceived sensory attributes of fluticasone furoate nasal spray (FFNS) and mometasone furoate nasal spray (MFNS) in AR patients.
METHODS:

In a multicenter, randomized, crossover, prospective study, 40 seasonal AR patients were administered both FFNS and MFNS for 2 weeks each in a crossover fashion, for a total of 4 weeks. Patients completed questionnaires for each product regarding perceived sensory attributes at the end of each two-week period of product administration.
RESULTS:

FFNS was significantly preferred over MFNS. Significantly, fewer subjects perceived a bitter taste (p=0.01), medication running down their throat (p=0.033), and medication running out of their nose (p=0.002) with FFNS. MFNS was more frequently reported to induce nasal irritation (p=0.012), sneezing (p=0.017), and rhinorrhea (p=0.007) compared to FFNS. Interestingly, these findings were markedly observed in females. Medicine dripping out of the nose and nasal shooting were the most common problems reported for MFNS with a higher proportion of subjects who felt moderate-to-severe discomfort. Overall, 52.5% of patients expressed a preference for FFNS compared with 22.5% for MFNS.
CONCLUSION:

Several perceived sensory attributes of FFNS were rated significantly superior to MFNS. FFNS may contribute to enhanced treatment outcomes in AR patients due to improved treatment adherence.

KEYWORDS:

Allergic rhinitis; Fluticasone furoate nasal spray; Intranasal corticosteroid spray; Mometasone furoate nasal spray; Perceived sensory attribute

(医博乙282)

Author
著者 米崎 雅史
著者(ヨミ) ヨネザキ マサフミ
著者(別表記) Yonezaki Masafumi
Publication Title
Auris Nasus Larynx
Publication Title Alternative
Auris Nasus Larynx.
Volume
43
Issue
3
Start Page
292
End Page
297
Publisher
Oto-Rhino-Laryngological Society of Japan
日本耳鼻咽喉科学会
Elsevier
Published Date
2015-10-21
ISSN
0385-8146
NCID
AA00061157
PMID
26498699
DOI
10.1016/j.anl.2015.09.003
Resource Type
Thesis or Dissertation
Language
eng
Relation
出版社版DOIリンク(URL): https://doi.org/10.1016/j.anl.2015.09.003
Rights
出版社版URL : https://doi.org/10.1016/j.anl.2015.09.003
Text Version
none
Grant ID
博乙第282号
Grant Date
2017-11-15
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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