Relationship between prolonged neural suppression and cerebral hemodynamic dysfunction during hypothermia in asphyxiated piglets

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28557
Title
Relationship between prolonged neural suppression and cerebral hemodynamic dysfunction during hypothermia in asphyxiated piglets
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Description

Abstract
OBJECTIVES:

Hypothermia (HT) improves the outcome of neonatal hypoxic-ischemic encephalopathy. Here, we investigated changes during HT in cortical electrical activity using amplitude-integrated electroencephalography (aEEG) and in cerebral blood volume (CBV) and cerebral hemoglobin oxygen saturation using near-infrared time-resolved spectroscopy (TRS) and compared the results with those obtained during normothermia (NT) after a hypoxic-ischemic (HI) insult in a piglet model of asphyxia. We previously reported that a greater increase in CBV can indicate greater pressure-passive cerebral perfusion due to more severe brain injury and correlates with prolonged neural suppression during NT. We hypothesized that when energy metabolism is suppressed during HT, the cerebral hemodynamics of brains with severe injury would be suppressed to a greater extent, resulting in a greater decrease in CBV during HT that would correlate with prolonged neural suppression after insult.
METHODS:

Twenty-six piglets were divided into four groups: control with NT (C-NT, n = 3), control with HT (C-HT, n = 3), HI insult with NT (HI-NT, n = 10), and HI insult with HT (HI-HT, n = 10). TRS and aEEG were performed in all groups until 24 h after the insult. Piglets in the HI-HT group were maintained in a hypothermic state for 24 h after the insult.
RESULTS:

There was a positive linear correlation between changes in CBV at 1, 3, 6, and 12 h after the insult and low-amplitude aEEG (<5 µV) duration after insult in the HI-NT group, but a negative linear correlation between these two parameters at 6 and 12 h after the insult in the HI-HT group. The aEEG background score and low-amplitude EEG duration after the insult did not differ between these two groups.
DISCUSSION AND CONCLUSION:

A longer low-amplitude EEG duration after insult was associated with a greater CBV decrease during HT in the HI-HT group, suggesting that brains with more severe neural suppression could be more prone to HT-induced suppression of cerebral metabolism and circulation.

KEYWORDS:

Animal model; Cerebral blood volume; Cerebral hemoglobin oxygen saturation; Electroencephalography; Hypothermic therapy; Hypoxia-ischemia; Hypoxic-ischemic encephalopathy; Near-infrared time-resolved spectroscopy; Piglet

(医博甲698)

Author
著者 神内 済
著者(ヨミ) ジンナイ ワタル
著者(別表記) Jinnai Wataru
Publication Title
Brain and Development
Publication Title Alternative
Brain Dev.
Volume
40
Issue
8
Start Page
649
End Page
661
Publisher
Japanese Society of Child Neurology
日本小児神経学会
Elsevier
Published Date
2018-05-19
ISSN
1872-7131
NCID
AA00111153
PMID
29789202
DOI
10.1016/j.braindev.2018.04.010
Resource Type
Thesis or Dissertation
Language
eng
Relation
出版社版URL : https://doi.org/10.1016/j.braindev.2018.04.010
Resource URL
https://doi.org/10.1016/j.braindev.2018.04.010
Relation(isVersionOf)
Publisher's Version.
Rights
エルゼビア・ジャパンに著作権ポリシーを確認した結果、リポジトリでの公開可能を確認した。 / As a result of confirming the copyright policy to Elsevier Japan, we confirmed the possibility of publishing in the repository.
出版社版URL : https://doi.org/10.1016/j.braindev.2018.04.010
Text Version
ETD
Grant ID
博甲第698号
Grant Date
2018-09-27
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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