SNX-2112 Induces Apoptosis and Autophagy of Nara-H Cells

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28571
タイトル
SNX-2112 Induces Apoptosis and Autophagy of Nara-H Cells
ファイル
内容記述

Abstract
BACKGROUND/AIM:

Selective heat shock protein 90 (Hsp90) inhibitor SNX-2112 exhibits antitumor activity in multiple cancer cell types. Here, the antitumor activity of SNX-2112 in Nara-H cells was analyzed.
MATERIALS AND METHODS:

Antitumor activity of SNX-2112 was assessed using a cell proliferation assay. We also examined the signalling pathways involved in SNX-2112-mediated autophagy and apoptosis of Nara-H cells by western blot and morphological analyses.
RESULTS:

Cell proliferation assays demonstrated that SNX-2112 inhibited Nara-H cell growth. Western blotting revealed that SNX-2112 induced apoptosis and autophagy, inhibited mammalian target of rapamycin (mTOR) phosphorylation, and suppressed the mitogen-activated protein kinase (MAPK) signalling pathway. Morphological analysis confirmed that SNX-2112 induced autophagy and apoptosis.
CONCLUSION:

SNX-2112 induced autophagy and apoptosis of Nara-H cells by inhibiting mTOR and MAPK pathways. Our results support developing SNX-2112 to treat human soft tissue sarcomas.

KEYWORDS:

SNX-2112; apoptosis; autophagy; undifferentiated pleomorphic sarcoma

著者
著者 福岡 奈津子
著者(ヨミ) フクオカ ナツコ
著者(別表記) Fukuoka Natsuko
掲載誌
Anticancer Research
38
9
開始ページ
5177
終了ページ
5181
出版者
International Institute of Anticancer Research
出版年月日
2018-09
ISSN
0250-7005
PMID
30194165
DOI
10.21873/anticanres.12840
資料タイプ
学位論文
言語
英語
関連情報
出版社版DOIリンク(URL): https://doi.org/10.21873/anticanres.12840
関連情報URL
https://doi.org/10.21873/anticanres.12840
博士論文(全文を含む)
学位授与番号
博甲第699号
学位授与年月日
2018-12-26
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
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