Histidine-rich Glycoprotein Could Be an Early Predictor of Vasospasm after Aneurysmal Subarachnoid Hemorrhage

( Max 2000 Items )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28668
Title
Histidine-rich Glycoprotein Could Be an Early Predictor of Vasospasm after Aneurysmal Subarachnoid Hemorrhage
File
Description

Abstract

Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2'-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS.

KEYWORDS:

biomarker; histidine-rich glycoprotein; predictor; subarachnoid hemorrhage; vasospasm

(医博甲704)

Author
著者 松本 淳志
著者(ヨミ) マツモト アツシ
著者(別表記) Matsumoto Atsushi
Publication Title
Acta Medica Okayama
Publication Title Alternative
Acta Med Okayama.
Volume
73
Issue
1
Start Page
29
End Page
39
Publisher
Okayama University Medical School
岡山大学医学部
Publisher Aalternative
岡山大学医学部
Published Date
2019-02
ISSN
0386-300X
NCID
AA00508441
PMID
30820052
DOI
10.18926/AMO/56456
Resource Type
Thesis or Dissertation
Language
eng
Relation
出版社版DOIリンク(URL) : https://doi.org/10.18926/AMO/56456
Resource URL
https://doi.org/10.18926/AMO/56456
Rights
CopyrightⒸ 2019 by Okayama University Medical School
https://doi.org/10.18926/AMO/56456
Text Version
ETD
Grant ID
博甲第704号
Grant Date
2019-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.