Clinical Features of Treated and Untreated Type 1 Idiopathic Macular Telangiectasia Without the Occurrence of Secondary Choroidal Neovascularization Followed for 2 Years in Japanese Patients

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Title
Clinical Features of Treated and Untreated Type 1 Idiopathic Macular Telangiectasia Without the Occurrence of Secondary Choroidal Neovascularization Followed for 2 Years in Japanese Patients
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Description

Abstract
PURPOSE:

To evaluate the clinical features of Type 1 idiopathic macular telangiectasia (IMT) followed up for 2 years.
METHODS:

Forty-nine patients with unilateral Type 1 IMT were examined. Thirty-one IMT eyes were treated with direct laser photocoagulation and/or intravitreal bevacizumab; the remaining 18 eyes, with good vision or slight macular edema, were untreated. Changes in best-corrected visual acuity and central retinal thickness between baseline and 24 months after the initial visit were examined.
RESULTS:

Of 49 eyes, nine were treated with direct laser photocoagulation, 12 with laser photocoagulation and intravitreal bevacizumab, 10 with intravitreal bevacizumab monotherapy, whereas 18 did not receive any treatment. The mean logarithm of the minimum angle of resolution best-corrected visual acuity was 0.20 ± 0.19 (median, 20/29) and 0.13 ± 0.22 (median, 20/25) at baseline and 24 months, respectively (P = 0.023). The mean central retinal thickness was 375.0 ± 94.5 μm and 315.3 ± 78.5 μm at baseline and 24 months, respectively (P < 0.001). Retinal vein occlusion and retinal macroaneurysm occurred in six eyes and one eye, respectively, during follow-up.
CONCLUSION:

Treatment with laser photocoagulation and/or intravitreal bevacizumab may be effective for Type 1 IMT, 36.7% of IMT eyes required no treatment over a 2-year follow-up, and other retinal vascular events were not uncommon.

Keywords:

Type 1 idiopathic macular telangiectasia; macular edema; intravitreal anti-vascular endothelial growth factor; intravitreal bevacizumab; laser photocoagulation; retinal vein occlusion; retinal macroaneurysm; vascular permeability

(医博甲706)

Author
著者 逢坂 理恵
著者(ヨミ) オオサカ リエ
著者(別表記) Osaka Rie
Publication Title
RETINA
Publication Title Alternative
Retina
Volume
38
Start Page
S114
End Page
S122
Publisher
Ophthalmic Communications Society
Lippincott, Williams & Wilkins
Published Date
2018-01-01
ISSN
0275-004X
NCID
AA10639923
PMID
28541960
DOI
10.1097/IAE.0000000000001724
Resource Type
Thesis or Dissertation
Language
eng
Relation
出版社版DOIリンク(URL) : https://doi.org/10.1097/IAE.0000000000001724
PMCID: PMC5753814 DOI
Resource URL
https://doi.org/10.1097/IAE.0000000000001724
https://insights.ovid.com/pubmed?pmid=28541960
https://journals.lww.com/retinajournal/fulltext/2018/01001/CLINICAL_FEATURES_OF_TREATED_AND_UNTREATED_TYPE_1.16.aspx
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753814/
Relation(isVersionOf)
Publisher's Version
Text Version
ETD
Grant ID
博甲第706号
Grant Date
2019-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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