Once-weekly teriparatide treatment prevents microdamage accumulation in the lumbar vertebral trabecular bone of ovariectomized cynomolgus monkeys

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28670
Title
Once-weekly teriparatide treatment prevents microdamage accumulation in the lumbar vertebral trabecular bone of ovariectomized cynomolgus monkeys
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Description

Abstract

The effect of teriparatide treatment on microdamage accumulation has yet to be examined in animal studies. The purpose of this study was to investigate the effect of once-weekly teriparatide treatment on bone microdamage accumulation and the relationship between microdamage parameters and bone mass, architecture, turnover, and collagen cross-linking in the lumbar vertebral trabecular bone of ovariectomized (OVX) cynomolgus monkeys. Female monkeys were divided into four groups (n = 18-20 per group): (1) SHAM group, (2) OVX group, (3) OVX with 1.2 µg/kg once-weekly teriparatide group (LOW group), (4) OVX with 6.0 µg/kg once-weekly teriparatide group (HIGH group). After 18 months, all animals were double-labeled with calcein for histomorphometry. L3 and L7 lumbar vertebrae were harvested and analyzed for differences in histomorphometry, microdamage, and collagen cross-linking. The iliac crest was also analyzed for differences in bone turnover. In the OVX group, cancellous bone mass was reduced and microdamage accumulation was increased as compared with the SHAM control. Once-weekly teriparatide at both doses prevented the decrease in bone mass and increase in microdamage accumulation, and improved the distribution of collagen cross-linkage types. Regression analyses indicated that decreased microdamage accumulation was associated with reduced non-enzymatic cross-link pentosidine rather than increased cancellous bone mass or enzymatic cross-links. These findings suggest that once-weekly teriparatide treatment decreases microdamage accumulation by recovering the balance in collagen cross-links.

KEYWORDS:

Bone histomorphometry; Bone microdamage; Collagen cross-links; Monkey; Teriparatide

(医博甲705)

Author
著者 吉武 新悟
著者(ヨミ) ヨシタケ シンゴ
著者(別表記) Yoshitake Shingo
Publication Title
Calcified Tissue International
Publication Title Alternative
Calcif Tissue Int.
Volume
104
Issue
4
Start Page
402
End Page
410
Publisher
International Osteoporosis Foundation
Springer
Published Date
2018-12-18
ISSN
0171-967X
NCID
AA00141085
PMID
30564860
DOI
10.1007/s00223-018-0500-7
Resource Type
Thesis or Dissertation
Language
eng
Relation
出版社版DOIリンク(URL): https://doi.org/10.1007/s00223-018-0500-7
Resource URL
https://doi.org/10.1007/s00223-018-0500-7
Relation(isVersionOf)
Publisher's Version.
Rights
Payd Open Access(Springer Open Choice).
"This is the Publisher's version of the following article: Once-weekly teriparatide treatment prevents microdamage accumulation in the lumbar vertebral trabecular bone of ovariectomized cynomolgus monkeys; Calcified Tissue International; Volume 104, Issue 4, (2018) Pages 402-410; doi: 10.1007/s00223-018-0500-7, which has been published in final form at https://doi.org/10.1007/s00223-018-0500-7 . "
DOI: https://doi.org/10.1007/s00223-018-0500-7
Text Version
ETD
Grant ID
博甲第705号
Grant Date
2019-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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