Once-weekly teriparatide treatment prevents microdamage accumulation in the lumbar vertebral trabecular bone of ovariectomized cynomolgus monkeys
URI | http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28670 | ||||||
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Title |
Once-weekly teriparatide treatment prevents microdamage accumulation in the lumbar vertebral trabecular bone of ovariectomized cynomolgus monkeys
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Description |
Abstract The effect of teriparatide treatment on microdamage accumulation has yet to be examined in animal studies. The purpose of this study was to investigate the effect of once-weekly teriparatide treatment on bone microdamage accumulation and the relationship between microdamage parameters and bone mass, architecture, turnover, and collagen cross-linking in the lumbar vertebral trabecular bone of ovariectomized (OVX) cynomolgus monkeys. Female monkeys were divided into four groups (n = 18-20 per group): (1) SHAM group, (2) OVX group, (3) OVX with 1.2 µg/kg once-weekly teriparatide group (LOW group), (4) OVX with 6.0 µg/kg once-weekly teriparatide group (HIGH group). After 18 months, all animals were double-labeled with calcein for histomorphometry. L3 and L7 lumbar vertebrae were harvested and analyzed for differences in histomorphometry, microdamage, and collagen cross-linking. The iliac crest was also analyzed for differences in bone turnover. In the OVX group, cancellous bone mass was reduced and microdamage accumulation was increased as compared with the SHAM control. Once-weekly teriparatide at both doses prevented the decrease in bone mass and increase in microdamage accumulation, and improved the distribution of collagen cross-linkage types. Regression analyses indicated that decreased microdamage accumulation was associated with reduced non-enzymatic cross-link pentosidine rather than increased cancellous bone mass or enzymatic cross-links. These findings suggest that once-weekly teriparatide treatment decreases microdamage accumulation by recovering the balance in collagen cross-links. KEYWORDS: Bone histomorphometry; Bone microdamage; Collagen cross-links; Monkey; Teriparatide (医博甲705) |
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Author |
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Publication Title |
Calcified Tissue International
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Publication Title Alternative |
Calcif Tissue Int.
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Volume |
104
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Issue |
4
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Start Page |
402
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End Page |
410
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Publisher |
International Osteoporosis Foundation
Springer
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Published Date |
2018-12-18
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ISSN |
0171-967X
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NCID |
AA00141085
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PMID |
30564860
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DOI |
10.1007/s00223-018-0500-7
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Resource Type |
Thesis or Dissertation
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Language |
eng
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Relation |
出版社版DOIリンク(URL): https://doi.org/10.1007/s00223-018-0500-7
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Resource URL |
https://doi.org/10.1007/s00223-018-0500-7
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Relation(isVersionOf) |
Publisher's Version.
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Rights |
Payd Open Access(Springer Open Choice).
"This is the Publisher's version of the following article: Once-weekly teriparatide treatment prevents microdamage accumulation in the lumbar vertebral trabecular bone of ovariectomized cynomolgus monkeys; Calcified Tissue International; Volume 104, Issue 4, (2018) Pages 402-410; doi: 10.1007/s00223-018-0500-7, which has been published in final form at https://doi.org/10.1007/s00223-018-0500-7 . "
DOI: https://doi.org/10.1007/s00223-018-0500-7
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Text Version |
ETD
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Grant ID |
博甲第705号
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Grant Date |
2019-03-24
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Degree Name |
博士(医学)
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Grantor |
香川大学
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Set |
香川大学
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