Macular atrophy findings by optical coherence tomography angiography compared with fundus autofluorescence in treated exudative age-related macular degeneration

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28672
Title
Macular atrophy findings by optical coherence tomography angiography compared with fundus autofluorescence in treated exudative age-related macular degeneration
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Description

Abstract
PURPOSE:

To compare the areas of choriocapillaris (CC) nonperfusion and macular atrophy (MA) in treated exudative age-related macular degeneration.
METHODS:

This was a prospective, observational, cross-sectional study. Forty-four eyes exhibiting MA (42 patients with age-related macular degeneration), with a dry macula, underwent fundus autofluorescence and optical coherence tomography angiography. The area of MA detected by fundus autofluorescence and CC nonperfusion detected by optical coherence tomography angiography was measured using image analysis software. The rates of concordance between the MA and CC nonperfusion areas were calculated. We qualitatively and quantitatively compared the areas of MA and CC nonperfusion in age-related macular degeneration eyes.
RESULTS:

The mean areas of MA and CC nonperfusion were 5.95 ± 4.50 mm and 10.66 ± 7.05 mm, respectively (paired t-test, P < 0.001). In 39 eyes (88.6%), the CC nonperfusion area was larger than the MA area, and the mean CC nonperfusion area was significantly larger than the mean MA area. Fundus autofluorescence matching optical coherence tomography angiography showed that the CC nonperfusion area was almost included in the MA area. The mean concordance rate for the MA area inside the CC nonperfusion area was 87.7 ± 13.9%.
CONCLUSION:

The MA and CC nonperfusion areas markedly overlapped. The area of CC nonperfusion correlated with the MA area. Choroidal ischemia might be involved in the pathogenesis of MA in treated age-related macular degeneration.

Keywords:

macular atrophy; choriocapillaris nonperfusion; fundus autofluorescence; optical coherence tomography angiography; exudative age-related macular degeneration; choroidal ischemia

(医博甲709)

Author
著者 高砂 縁
著者(ヨミ) タカサゴ ユカリ
著者(別表記) Takasago yukari
Publication Title
RETINA
Publication Title Alternative
Retina
Volume
39
Issue
2
Start Page
296
End Page
302
Publisher
Ophthalmic Communications Society
Lippincott, Williams & Wilkins
Published Date
2019-02-01
ISSN
0275-004X
NCID
AA10639923
PMID
29190232
DOI
10.1097/IAE.0000000000001980
Resource Type
Thesis or Dissertation
Language
eng
Relation
出版社版DOIリンク(URL): https://doi.org/10.1097/IAE.0000000000001980
PMCID:PMC6358286
Resource URL
https://doi.org/10.1097/IAE.0000000000001980
https://insights.ovid.com/crossref?an=00006982-201902000-00010
https://journals.lww.com/retinajournal/fulltext/2019/02000/MACULAR_ATROPHY_FINDINGS_BY_OPTICAL_COHERENCE.10.aspx
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358286/
Rights
Open Acccess
Text Version
ETD
Grant ID
博甲第709号
Grant Date
2019-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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