Effects of the expectorant drug ambroxol hydrochloride on chemically induced lung inflammatory and neoplastic lesions in rodents

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28675
Title
Effects of the expectorant drug ambroxol hydrochloride on chemically induced lung inflammatory and neoplastic lesions in rodents
File
Description

Abstract

Ambroxol hydrochloride (AH) is an expectorant drug used to stimulate pulmonary surfactant and serous airway secretion. Surfactant proteins (SPs) are essential for maintaining respiratory structure and function, although SP expression has also been reported in lung inflammatory and proliferative lesions. To determine whether AH exerts modulatory effects on these lung lesions, we examined its effects on pleural thickening induced by intrathoracic administration of dipotassium titanate (TISMO) in A/JJmsSlc (A/J) mice. We also analyzed the modulatory effects of AH on neoplastic lung lesions induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice and by N-nitrosobis (2-hydroxypropyl) amine (DHPN) in F344/DuCrlCrj (F344) rats. A/J mice treated with TISMO showed decreased body weight, increased white blood cell (WBC) counts, and pleural thickening caused by pleuritis and poor general condition. However, A/J mice treated with TISMO + 120 ppm showed significant recovery of body weight and WBC counts to the same levels as those of A/J mice not treated with TISMO, although no significant differences were observed in histopathological changes including the immunohistopathological expression of IL-1β in the lung and maximum pleural thickness regardless of AH treatment. In the NNK and DHPN experiments, no significant differences in body weight, hematology, plasma biochemistry, and histopathological changes were associated with AH concentration. These results suggest that AH potentially exerts anti-inflammatory effects but does not have a direct suppressive effect on lung tumorigenesis in rodents.

KEYWORDS:

DHPN; NNK; TISMO; ambroxol hydrochloride; lung carcinogenesis; lung inflammation

(医博甲712)

Author
著者 吉田 翔太
著者(ヨミ) ヨシダ ショウタ
著者(別表記) Yoshida Shota
Publication Title
Journal of Toxicologic Pathology
Publication Title Alternative
J Toxicol Pathol.
Volume
31
Issue
4
Start Page
255
End Page
265
Publisher
Japanese Society of Toxicologic Pathology
日本毒性病理学会
Published Date
2018-01-09
ISSN
0914-9198
NCID
AN10232280
PMID
30393429
DOI
10.1293/tox.2018-0012
Resource Type
Thesis or Dissertation
Language
eng
Relation
出版社版DOIリンク(URL): https://doi.org/10.1293/tox.2018-0012
PMCID: PMC6206285
Resource URL
https://doi.org/10.1293/tox.2018-0012
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206285/
Rights
Copyright ©2018 The Japanese Society of Toxicologic Pathology, DOI:https://doi.org/10.1293/tox.2018-0012
"This is the Publisher's version of the following article: Effects of the expectorant drug ambroxol hydrochloride on chemically induced lung inflammatory and neoplastic lesions in rodents; Journal of Toxicologic Pathology; Volume 31 Number4 (2018) 255-265; doi: 10.1293/tox.2018-0012, which has been published in final form at https://doi.org/10.1293/tox.2018-0012 . "
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/).
この論文の利用は、上記に掲載した著作権の範囲内に限られる。(Use of this article is limited to the scope of the copyrights listed above.)
Text Version
ETD
Grant ID
博甲第712号
Grant Date
2019-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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