Effects of the expectorant drug ambroxol hydrochloride on chemically induced lung inflammatory and neoplastic lesions in rodents

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28675
タイトル
Effects of the expectorant drug ambroxol hydrochloride on chemically induced lung inflammatory and neoplastic lesions in rodents
ファイル
内容記述

Abstract

Ambroxol hydrochloride (AH) is an expectorant drug used to stimulate pulmonary surfactant and serous airway secretion. Surfactant proteins (SPs) are essential for maintaining respiratory structure and function, although SP expression has also been reported in lung inflammatory and proliferative lesions. To determine whether AH exerts modulatory effects on these lung lesions, we examined its effects on pleural thickening induced by intrathoracic administration of dipotassium titanate (TISMO) in A/JJmsSlc (A/J) mice. We also analyzed the modulatory effects of AH on neoplastic lung lesions induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice and by N-nitrosobis (2-hydroxypropyl) amine (DHPN) in F344/DuCrlCrj (F344) rats. A/J mice treated with TISMO showed decreased body weight, increased white blood cell (WBC) counts, and pleural thickening caused by pleuritis and poor general condition. However, A/J mice treated with TISMO + 120 ppm showed significant recovery of body weight and WBC counts to the same levels as those of A/J mice not treated with TISMO, although no significant differences were observed in histopathological changes including the immunohistopathological expression of IL-1β in the lung and maximum pleural thickness regardless of AH treatment. In the NNK and DHPN experiments, no significant differences in body weight, hematology, plasma biochemistry, and histopathological changes were associated with AH concentration. These results suggest that AH potentially exerts anti-inflammatory effects but does not have a direct suppressive effect on lung tumorigenesis in rodents.

KEYWORDS:

DHPN; NNK; TISMO; ambroxol hydrochloride; lung carcinogenesis; lung inflammation

(医博甲712)

著者
著者 吉田 翔太
著者(ヨミ) ヨシダ ショウタ
著者(別表記) Yoshida Shota
掲載誌
Journal of Toxicologic Pathology
掲載誌(別表記)
J Toxicol Pathol.
31
4
開始ページ
255
終了ページ
265
出版者
Japanese Society of Toxicologic Pathology
日本毒性病理学会
出版年月日
2018-01-09
ISSN
0914-9198
NCID
AN10232280
PMID
30393429
DOI
10.1293/tox.2018-0012
資料タイプ
学位論文
言語
英語
関連情報
出版社版DOIリンク(URL): https://doi.org/10.1293/tox.2018-0012
PMCID: PMC6206285
関連情報URL
https://doi.org/10.1293/tox.2018-0012
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206285/
権利関係
Copyright ©2018 The Japanese Society of Toxicologic Pathology, DOI:https://doi.org/10.1293/tox.2018-0012
"This is the Publisher's version of the following article: Effects of the expectorant drug ambroxol hydrochloride on chemically induced lung inflammatory and neoplastic lesions in rodents; Journal of Toxicologic Pathology; Volume 31 Number4 (2018) 255-265; doi: 10.1293/tox.2018-0012, which has been published in final form at https://doi.org/10.1293/tox.2018-0012 . "
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/).
この論文の利用は、上記に掲載した著作権の範囲内に限られる。(Use of this article is limited to the scope of the copyrights listed above.)
博士論文(全文を含む)
学位授与番号
博甲第712号
学位授与年月日
2019-03-24
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
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