Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest
URI | http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28734 | ||||||
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Title |
Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest
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Description |
Abstract Cholangiocarcinoma is the most common biliary malignancy and the second most common hepatic malignancy after hepatocellular carcinoma (HCC). Galectin-9 (Gal-9) is a tandem-repeat-type galectin that has recently been shown to exert antiproliferative effects on cancer cells. Therefore, the present study evaluated the effects of Gal-9 on the proliferation of human cholangiocarcinoma cells in vitro as well as the microRNAs (miRNAs) associated with the antitumor effects of Gal-9. Gal-9 suppressed the proliferation of cholangiocarcinoma cell lines in vitro and the growth of human cholangiocarcinoma cell xenografts in nude mice. Our data further revealed that Gal-9 increased caspase‑cleaved keratin 18 (CCK18) levels, and the expression of cytochrome c increased in Gal-9-treated cholangiocarcinoma cell lines. These data suggested that Gal-9 induced cholangiocarcinoma cell apoptosis via the intrinsic apoptosis pathway mediated by caspase-dependent or -independent pathways. In addition, Gal-9 reduced the phosphorylation of the epidermal growth factor receptor (EGFR), insulin-like growth factor and insulin-like growth factor-1 receptor (IGF-1R), hepatocyte growth factor receptor and fibroblast growth factor receptor 3 (FGFR3). These findings suggest that Gal-9 can be a candidate of therapeutic target in the treatment of cholangiocarcinoma. (医博甲616) |
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Author |
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Publication Title |
Oncology Reports
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Publication Title Alternative |
Oncol Rep.
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Volume |
34
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Issue |
4
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Start Page |
1761
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End Page |
1770
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Publisher |
Spandidos Publications
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Published Date |
2015-08-10
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ISSN |
1021-335X
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NCID |
AA11016405
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PMID |
26260906
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DOI |
10.3892/or.2015.4197
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Resource Type |
Thesis or Dissertation
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Language |
eng
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Resource URL |
https://doi.org/10.3892/or.2015.4197
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Rights |
Copyright © Spandidos Publications 2015.
"This is the Publisher's version of the following article: Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest; Oncology Reports; Volume 34 Issue 4 (2015) Pages: 1761-1770; doi:10.3892/or.2015.4197, which has been published in final form at https://doi.org/10.3892/or.2015.4197 . "
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Text Version |
ETD
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Grant ID |
博甲第616号
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Grant Date |
2015-09-29
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Degree Name |
博士(医学)
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Grantor |
香川大学
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Set |
香川大学
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