Urinary Angiotensinogen Could be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes

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Title
Urinary Angiotensinogen Could be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes
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Description

Abstract
BACKGROUND:

The aims of this study were (1) to examine the renoprotective effects of alogliptin and (2) to establish urinary angiotensinogen (AGT) as a prognostic marker of renoprotective effects of alogliptin in patients with type 2 diabetes (T2D).
METHODS:

In 43 patients with T2D (18 women, 66.1 ± 1.71 years), 25 mg/day of alogliptin was added to the traditional hypoglycemic agents and/or nondrug treatments. Urinary concentrations of albumin (Alb) and AGT, normalized by urinary concentrations of creatinine (Cr) (UAlbCR and UAGTCR, respectively), were measured before and after the 12-week alogliptin treatment.
RESULTS:

Alogliptin treatment tended to decrease UAlbCR (99.6 ± 26.8 versus 114.6 ± 36.0 mg/g Cr, P = 0.198). Based on % change in UAlbCR, patients were divided into two groups, responders (< -25%) and nonresponders (≥ -25%), and a logistic analysis of UAGTCR before treatment showed cutoff value of 20.8 µg/g Cr. When all patients were redivided into two groups, those with higher values of UAGTCR before the treatment (Group H, n = 20) and those with lower values (Group L), Group H showed significantly decreased UAlbCR in response to alogliptin (-14.6 ± 8.6 versus +22.8 ± 16.8%, P = 0.033).
CONCLUSION:

Urinary AGT could be a prognostic marker of renoprotective effects of alogliptin in patients with T2D.

(医博甲629)

Author
著者 水重 知子
著者(ヨミ) ミズシゲ トモコ
著者(別表記) Mizushige Tomoko
Publication Title
Journal of Diabetes Research
Publication Title Alternative
J Diabetes Res.
Volume
2015
Publisher
Hindawi
Published Date
2015-08-25
ISSN
2314-6745
PMID
26380312
DOI
10.1155/2015/517472
Resource Type
Thesis or Dissertation
Language
eng
Relation
PMCID: PMC4562181
Resource URL
https://doi.org/10.1155/2015/517472
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562181/
Rights
Copyright © 2015 Tomoko Mizushige et al.
This is an open access article distributed under the Creative Commons Attribution License(http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Text Version
ETD
Grant ID
博甲第629号
Grant Date
2016-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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