Image accuracy and quality test in rate constant depending on reconstruction algorithms with and without incorporating PSF and TOF in PET imaging

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28753
Title
Image accuracy and quality test in rate constant depending on reconstruction algorithms with and without incorporating PSF and TOF in PET imaging
File
Description

Abstract
OBJECTIVE:

Positron emission tomography allows imaging of patho-physiological information as a form of rate constants from scanned and reconstructed dynamic image. Some reconstruction algorithms incorporated with time of flight and point spread function have been developed, and quantitative accuracy and quality in the image have been investigated. However, feasibility of the rate constants from the dynamic image has not been directly investigated. We investigated the accuracy and quality in the rate constant by scanning a phantom filled simultaneously with (11)C and (18)F.
METHOD:

We utilized a phantom filled with (18)F-F(-) solution in the main cylinder and with (11)C-flumazenil solution in seven sub-cylinders. The phantom was scanned by a Biograph mCT and the scanned data were reconstructed with FBP- and OSEM-based algorithms incorporating with and without TOF and/or PSF corrections. Decay rate images as kinetic rate constant were computed for all the reconstructed images and quantitative accuracy and quality in the rate images were investigated.
RESULTS:

The obtained decay rates were not significantly different from the reference values for both isotopes for all applied algorithms when noise on image was not large. Respective SD was smaller in OSEM with TOF in the (11)C-filled region.
CONCLUSION:

The present study suggests that OSEM incorporating with TOF provides reasonable quantitative accuracy and image quality regarding decay rates.

Keywords:
Feasibility test; Rate constant; Phantom; PET; Kinetic analysis;

(医博甲635)

Author
著者 前田 幸人
著者(ヨミ) マエダ ユキト
著者(別表記) Maeda Yukito
Publication Title
Annals of Nuclear Medicine
Publication Title Alternative
Ann Nucl Med.
Volume
29
Issue
7
Start Page
561
End Page
569
Publisher
Japanese Society of Nuclear Medicine
日本核医学会
Springer
Published Date
2015-05-06
ISSN
1342-078X
NCID
AA1108348X
PMID
25943347
DOI
10.1007/s12149-015-0979-1
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1007/s12149-015-0979-1
Rights
Publisher's Version with DOI: https://doi.org/10.1007/s12149-015-0979-1
Text Version
none
Grant ID
博甲第635号
Grant Date
2016-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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