The effect of memantine on sleep architecture and psychiatric symptoms in patients with Alzheimer's disease

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28754
Title
The effect of memantine on sleep architecture and psychiatric symptoms in patients with Alzheimer's disease
File
Description

Abstract
OBJECTIVE:

Behavioural and psychological symptoms of dementia (BPSD) are commonly present in patients with Alzheimer's disease (AD). Disturbed sleep quality is also observed in AD patients. However, the effects of memantine on sleep architecture have not been investigated. The purpose of this study was to investigate the effects of memantine on polysomnography (PSG) variables and BPSD.
METHODS:

In total, 12 patients with AD (mean age: 79.0±4.1 years old) were enrolled in this study. The following tests were performed: the Neuropsychiatric Inventory for the assessment of BPSD, the Mini-Mental State Examination (MMSE) for cognitive function, and PSG for evaluation of sleep architecture. After baseline examinations, patients were treated with memantine according to a standard prescription protocol. After being treated with 20 mg/day of memantine for 4 weeks, examinations were carried out again.
RESULTS:

All subjects completed the trial. The mean MMSE and NPI scores were 22.6±3.4 and 13.8±12.9, respectively. Treatment with memantine significantly decreased the NPI score (5.8±4.3, p<0.01). There were significant decreases in the scores of subscales for anxiety (p=0.04) and irritability/lability (p=0.04). PSG demonstrated a longer total sleep time (TST) (p<0.01), increases in sleep efficiency (p<0.01) and time spent in stage II (% TST, p=0.02), and decreases in nocturnal awakening (p<0.01), the periodic limb movement index (p<0.01), and time spent in stage I (% TST, p=0.02).
CONCLUSION:

Memantine was effective for reducing fragmented sleep and improving BPSD, and was well tolerated.

KEYWORDS:

Alzheimer’s disease; N-methyl-D-aspartate; behavioural and psychological symptoms of dementia (BPSD); periodic limb movement; polysomnography

(医博甲636)

Author
著者 石川 一朗
著者(ヨミ) イシカワ イチロウ
著者(別表記) Ishikawa Ichiro
Publication Title
Acta Neuropsychiatrica
Publication Title Alternative
Acta Neuropsychiatr.
Volume
28
Issue
3
Start Page
157
End Page
164
Publisher
Scandinavian College of NeuroPsychopharmacology
Cambridge University Press
Published Date
2015-11-17
ISSN
0924-2708
NCID
AA11703733
PMID
26572055
DOI
10.1017/neu.2015.61
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1017/neu.2015.61
Rights
Publisher's Version with DOI: https://doi.org/10.1017/neu.2015.61
Text Version
none
Grant ID
博甲第636号
Grant Date
2016-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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