Galectin-9 suppresses the proliferation of gastric cancer cells in vitro

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28755
Title
Galectin-9 suppresses the proliferation of gastric cancer cells in vitro
File
Description

Abstract

Gastric cancer is the second-leading cause of cancer-related mortality worldwide, and the prognosis of advanced gastric cancer remains poor. Galectin-9 (Gal-9) is a tandem-repeat-type galectin that has recently been demonstrated to exert anti-proliferative effects on various types of cancer cells. The aim of our present study was to evaluate the effects of Gal-9 on human gastric cancer cells and the expression levels of microRNAs (miRNAs) associated with the antitumor effects of Gal-9 in vitro. In our initial experiments, Gal-9 suppressed the proliferation of gastric cancer cell lines in vitro. Our data further revealed that Gal-9 increased caspase-cleaved keratin 18 (CCK18) levels in gastric cancer cells. Additionally, Gal-9 reduced the phosphorylation of vascular endothelial growth factor receptor-3 (VEGFR-3) and insulin-like growth factor-1 receptor (IGF-1R). Furthermore, miRNA expression levels were markedly altered with Gal-9 treatment in vitro. In conclusion, Gal-9 suppressed the proliferation of human gastric cancer cells by inducing apoptosis. These findings suggest that Gal-9 could be a potential therapeutic target in the treatment of gastric cancer.

(医博甲637)

Author
著者 髙野 実子
著者(ヨミ) タカノ ジツコ
著者(別表記) Takano Jitsuko
Publication Title
Oncology Reports
Publication Title Alternative
Oncol Rep.
Volume
35
Issue
2
Start Page
851
End Page
860
Publisher
Spandidos Publications
Published Date
2015-11-26
ISSN
1021-335X
NCID
AA11016405
PMID
26717877
DOI
10.3892/or.2015.4452
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.3892/or.2015.4452
Rights
Copyright © Spandidos Publications 2015.
"This is the Publisher's version of the following article: Galectin-9 suppresses the proliferation of gastric cancer cells in vitro; Oncology Reports; Volume 35 Issue 2 (2015) Pages: 851-860; doi: 10.3892/or.2015.4452, which has been published in final form at https://doi.org/10.3892/or.2015.4452 . "
Text Version
ETD
Grant ID
博甲第637号
Grant Date
2016-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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