Diagnostic Value of Flow Cytometry Standardized Using the European LeukemiaNet for Myelodysplastic Syndrome

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28808
Title
Diagnostic Value of Flow Cytometry Standardized Using the European LeukemiaNet for Myelodysplastic Syndrome
Title Alternative
骨髄異形成症候群の診断におけるELN基準表面マーカーの有用性
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Description

Abstract
BACKGROUND:

Myelodysplastic syndromes (MDS) and idiopathic cytopenia of undetermined significance (ICUS) are heterogeneous hematological disorders characterized by hematopoietic dysplasia and/or chromosomal aberrancy.
OBJECTIVES:

This study aimed to evaluate the diagnostic value of flow cytometry standardized using the European LeukemiaNet (ELN) for MDS and ICUS by analyzing samples obtained from patients with cytopenia based on morphological examination, cytogenetic analysis, and flow cytometry.
METHODS:

We retrospectively analyzed bone marrow samples aspirated from 253 consecutive patients (median age: 66 years [range: 1-92]) to identify the cause of cytopenia.
RESULTS:

Sixty patients presented with MDS, and 16 with ICUS. MDS subtypes were distributed as follows: MDS with single-lineage dysplasia (n = 10); MDS with multi-lineage dysplasia (n = 10); MDS with ringed sideroblasts (n = 4); MDS with excess blasts-1 (n = 9); MDS with excess blasts-2 (n = 13), MDS unclassified (n = 5); 5q-syndrome (n = 6); and MDS/myeloproliferative neoplasms (n = 3). Four representative ELN indexes were used. Two or more ELN MDS indexes were in the abnormal range in 35 MDS cases (58.3%) and 4 ICUS cases (25.0%).
CONCLUSIONS:

Morphological examination remains the standard for MDS diagnosis. Considering the low incidence of genetically proven ICUS (20.2-27.5%), the low sensitivity of ELN MDS indexes for ICUS is considered a valuable alternative.

KEYWORDS:

Cytopenia; Diagnostic index; European LeukemiaNet; Flow cytometry; Myelodysplastic syndrome

(医博甲725)

Author
著者 竹内 彰浩
著者(ヨミ) タケウチ アキヒロ
著者(別表記) Takeuchi Akihiro
Publication Title
Acta haematologica
Publication Title Alternative
Acta haematol.
Start Page
1
End Page
6
Publisher
Karger Publishers
Published Date
2019-07-22
ISSN
1421-9662
NCID
AA12780820
PMID
31330512
DOI
10.1159/000501147
Resource Type
Thesis or Dissertation
Language
eng
Relation
[Epub ahead of print]
Resource URL
http://sherpa.ac.uk/romeo/issn/0001-5792/
Rights
Copyright © 2019 S. Karger AG, Basel.
"This is the Accepted Version of the following article: Diagnostic Value of Flow Cytometry Standardized Using the European LeukemiaNet for Myelodysplastic Syndrome; Acta haematologica; [Epub ahead of print] (2019) Pages: 1-6; doi: 10.1159/000501147 , which has been published in final form at https://doi.org/10.1159/000501147 . "
Text Version
ETD
Grant ID
博甲第725号
Grant Date
2019-09-25
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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