Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28970
Title
Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.
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Description

Abstract

Despite its poor outcomes, therapeutic hypothermia (TH) is the current standard treatment for neonatal hypoxic-ischaemic encephalopathy (HIE). In this study, due to its antioxidant, anti-inflammatory, and antiapoptotic properties, the effectiveness of molecular hydrogen (H2) combined with TH was evaluated by means of neurological and histological assessments. Piglets were divided into three groups: hypoxic-ischaemic insult with normothermia (NT), insult with hypothermia (TH, 33.5 ± 0.5 °C), and insult with hypothermia with H2 ventilation (TH-H2, 2.1-2.7%). H2 ventilation and TH were administered for 24 h. After ventilator weaning, neurological assessment was performed every 6 h for 5 days. On day 5, the brains of the piglets were harvested for histopathological analysis. Regarding the neurological score, the piglets in the TH-H2 group consistently had the highest score from day 2 to 5 and showed a significantly higher neurological score from day 3 compared with the NT group. Most piglets in the TH-H2 group could walk at day 3 of recovery, whereas walking ability was delayed in the two other groups. The histological results revealed that TH-H2 tended to improve the status of cortical gray matter and subcortical white matter, with a considerable reduction in cell death. In this study, the combination of TH and H2 improved short-term neurological outcomes in neonatal hypoxic-ischaemic piglets.

(医博甲730)

Author
著者 YINMON HTUN
著者(ヨミ) インモン トゥン
著者(別表記) Yinmon Htun
Publication Title
Scientific Reports
Publication Title Alternative
Sci Rep.
Volume
9
Issue
1
Publisher
Nature Research
Published Date
2019-03-11
ISSN
2045-2322
PMID
30858437
DOI
10.1038/s41598-019-40674-8
Resource Type
Thesis or Dissertation
Language
eng
Relation
PMCID: PMC6411734
Resource URL
https://doi.org/10.1038/s41598-019-40674-8
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6411734/
Rights
Copyright © The Author(s) 2019
"This is the Publisher's Version of the following article: Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.; Scientific Reports; Volume 9 Article number: 4088 (2019) doi: 10.1038/s41598-019-40674-8, which has been published in final form at https://doi.org/10.1038/s41598-019-40674-8 . "
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Text Version
ETD
Grant ID
博甲第730号
Grant Date
2020-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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