Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28986
Title
Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
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Description

Abstract

Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated the effects of telmisartan on human ESCC cell proliferation in vitro and in vivo and sought to identify the microRNAs (miRNAs) involved in these antitumor effects. We examined the effects of telmisartan on three human ESCC cell lines (KYSE150, KYSE180, and KYSE850). Telmisartan inhibited proliferation of these three cell lines by inducing S-phase arrest, which was accompanied by decreased expression of cyclin A2, cyclin-dependent kinase 2, and other cell cycle-related proteins. Additionally, telmisartan reduced levels of phosphorylated ErbB3 and thrombospondin-1 in KYSE180 cells. Furthermore, expression of miRNAs was remarkably altered by telmisartan in vitro. Telmisartan also inhibited tumor growth in vivo in a xenograft mouse model. In conclusion, telmisartan inhibited cell proliferation and tumor growth in ESCC cells by inducing cell-cycle arrest.

Keywords:

angiotensin II type 1 receptor blocker; cell cycle arrest; cyclin; esophageal squamous cell carcinoma; telmisartan

(医博甲739)

Author
著者 松井 崇矩
著者(ヨミ) マツイ タカノリ
著者(別表記) Matsui Takanori
Publication Title
International journal of molecular sciences
Publication Title Alternative
Int J Mol Sci.
Volume
20
Issue
13
Publisher
MDPI
Published Date
2019-06-29
ISSN
1422-0067
NCID
AA12038549
PMID
31261874
DOI
10.3390/ijms20133197
Resource Type
Thesis or Dissertation
Language
eng
Relation
PMCID: PMC6651359
Resource URL
https://doi.org/10.3390/ijms20133197
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6651359/
Rights
Copyright © 2019 by the authors.
"This is the Publisher's Version of the following article: Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo; International journal of molecular sciences; Volume 20 Issue 13 (2019) 3197; doi: 10.3390/ijms20133197, which has been published in final form at https://doi.org/10.3390/ijms20133197 . "
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Text Version
ETD
Grant ID
博甲第739号
Grant Date
2020-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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