Effects of an SGLT2 inhibitor on the salt sensitivity of blood pressure and sympathetic nerve activity in a nondiabetic rat model of chronic kidney disease

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28987
タイトル
Effects of an SGLT2 inhibitor on the salt sensitivity of blood pressure and sympathetic nerve activity in a nondiabetic rat model of chronic kidney disease
ファイル
内容記述

Abstract

The glucose-lowering effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors is reduced in patients with diabetes who have chronic kidney disease (CKD). In the present study, we examined the effect of an SGLT2 inhibitor on the salt sensitivity of blood pressure (BP), circadian rhythm of BP, and sympathetic nerve activity (SNA) in nondiabetic CKD rats. Uninephrectomized Wistar rats were treated with adenine (200 mg/kg/day) for 14 days. After stabilization with a normal-salt diet (NSD, 0.3% NaCl), a high-salt diet (HSD, 8% NaCl) was administered. Mean arterial pressure (MAP) was continuously monitored using a telemetry system. We also analyzed the low frequency (LF) of systolic arterial pressure (SAP), which reflects SNA. In adenine-induced CKD rats, HSD consumption for 5 days significantly increased the mean MAP from 106 ± 2 to 148 ± 3 mmHg. However, MAP was decreased to 96 ± 3 mmHg within 24 h after switching back to a NSD (n = 7). Treatment with an SGLT2 inhibitor, luseogliflozin (10 mg/kg/day, p.o., n = 7), significantly attenuated the HSD-induced elevation of MAP, which was associated with a reduction in LF of SAP. These data suggest that treatment with an SGLT2 inhibitor attenuates the salt sensitivity of BP, which is associated with SNA inhibition in nondiabetic CKD rats.

Keywords:

Blood pressure; Chronic kidney disease; Rat; Salt; Sodium-glucose cotransporter 2 inhibitor; Sympathetic nerve activity

(医博甲740)

著者
著者 WAN NINGNING
著者(ヨミ) ワン ニンニン
著者(別表記) Wan Ningning
掲載誌
Hypertension research
掲載誌(別表記)
Hypertens Res.
出版者
Japanese Society of Hypertension
日本高血圧学会
Springer
出版年月日
2020-02-14
ISSN
0916-9636
NCID
AA12022378
PMID
32060381
DOI
10.1038/s41440-020-0410-8
資料タイプ
学位論文
言語
英語
権利関係
"This is the Accepted Version of the following article: Effects of an SGLT2 inhibitor on the salt sensitivity of blood pressure and sympathetic nerve activity in a nondiabetic rat model of chronic kidney disease; Hypertension research; [Online ahead of print] (2020); doi: 10.1038/s41440-020-0410-8, which has been published in final form at https://doi.org/10.1038/s41440-020-0410-8 . "
Non-commercial use only.
該当なし
学位授与番号
博甲第740号
学位授与年月日
2020-03-24
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
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